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Fasting Mimicking Diet and Autophagy

Diet Clinical Trial

Official title:
Cellular Effects of Fasting Mimicking Diet In Humans: An Interventional, Randomized, Open Label, Parallel Assignment Study

Clinical Trial Summary

This study aims to evaluates autophagy in circulating white blood cells from generally healthy human volunteers exposed to fasting mimicking diet (FMD), a 5-day dietary regimen.

Clinical Trial Description

Fasting-mimicking diet (FMD) was developed to mimic the endocrine and metabolic effects that water-only fasting, while providing a modest calories and essential nutrients. The health benefits of FMD are caused by several molecular mechanisms, including the reduction of body weight, ectopic fat storage, insulin levels, endogenous glucose production and IGF-1. Autophagy is a catabolic membrane-trafficking phenomenon observed in yeast and mammalian cells. Nutrient deprivation induces autophagy. Autophagy has been proposed to be a fundamental cellular process being linked to aging and the progression of age-related diseases. The objective of this study is to evaluate the effects of consuming two FMD formulations on the autophagy process in the cell. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06115551
Study type Interventional
Source L-Nutra Inc
Contact
Status Active, not recruiting
Phase N/A
Start date May 2, 2023
Completion date April 30, 2024
View Details
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