Diet-induced Thermogenesis Clinical Trial
Official title:
Is the Timing of Caloric Intake Associated With Variation in Diet-induced Thermogenesis and Hormonal Pattern?
The investigators aim at analyzing whether eating a standard meal in the evening (at 8:00 pm)
determines in the same individuals a lower diet-induced thermogenesis (DIT) and a different
hormonal response than the consumption of the same meal in the morning (at 8:00 am).
The primary outcome is: the intra-individual variation in DIT after the evening and morning
meal consumption.
The secondary outcomes are the intra-individual variations in glucose, triglyceride, insulin,
free fatty acids, leptin, glucagon-like peptide-1, acylated ghrelin, adrenalin, noradrenalin,
after the evening and morning meal consumption.
Twenty healthy volunteers (ten males and ten females) are recruited among students and
graduates attending the Department of Medical Sciences of Turin (Italy) to take part to this
randomized cross-over trial.
Participants randomly receive first the standard meal at 8:00 am and the week after the
standard meal at 8:00 pm or vice versa. Eight-h before the meal (respectively at 12:00 pm or
at 12:00 am), the participants receive the same standard meal (without protein
supplementation) at their home, and then are asked to spend in bed the following 6 hours. A
24-h urine collection is collected the day before each test in order to determine total
urinary nitrogen excretion.
The standard meal consists of: 100g white bread, 100g ham, 50g cheese, 125g yogurt, 200ml
fruit juice, plus 25g protein supplement. The participants must consume each meal in 25-30
minutes.
A 30-min basal calorimetric (Deltatrac II) exam is performed. Participants remain in a supine
position but awake and motionless on a hospital bed during the whole period, except during
the meal, when they can sit to eat. At 8:00 am (or pm), the participants consume the meal,
and then rest in a supine position for 90 min. Then, a second 60 min-calorimetric evaluation
is done. From the first calorimetric exam (the basal) until the end of the second
(post-prandial) blood samples are drawn every 30 min. The same time schedule is adopted in
the case of the morning meal (at 8:00 am) and the evening meal (at 8:00 pm).
The random sequence (morning/evening, evening/morning meal) is computer-generated, using
blocks of different lengths in random order.
The following are measured: weight, height, waist circumference, and at baseline and every
30-min during the morning and evening tests: glucose, triglyceride, insulin, free-fatty
acids, leptin, glucagon-like peptide-1, acylated ghrelin, adrenalin, noradrenalin.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04086381 -
Creatine Effect on Brown Adipose Tissue Activation
|
N/A |