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Diet, High-Fat clinical trials

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NCT ID: NCT05486598 Recruiting - Pharmacokinetics Clinical Trials

A Study of Diet Influence of AL8326 in Chinese Healthy Adult Subjects

Start date: June 21, 2022
Phase: Phase 1
Study type: Interventional

Main study objective: the pharmacokinetic effects of high-fat diet on AL8326 after oral administration of AL8326 tablets in Chinese healthy adult subjects. Secondary study objectives: safety and tolerability of a single oral dose of AL8326 tablets in healthy subjects

NCT ID: NCT04743271 Recruiting - Circadian Rhythm Clinical Trials

Food and Circadian Timing

FACT
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.

NCT ID: NCT02259153 Completed - Hyperlipidemias Clinical Trials

Effect of Different Fat Enriched Meats on the Hepatic Cholesterol Synthesis

Start date: March 2014
Phase: N/A
Study type: Interventional

The objective of the study is to assess the effect of two diets with different fat composition on cholesterol metabolism. The study was a randomized cross-over trial where volunteers follow two study periods with different types of meat (lean and fat red meat) separately by a ten days wash-out period. At the beginning of the study and after the study periods the following parameters are determined: anthropometric (weight, waist, circumference and body mass index), blood pressure, dietary (72-hours dietary registry) and exercise assessments and biochemical analysis (total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoprotein A1, apolipoprotein B, iron, transferring, ferritin, uric acid, glucose, HbA1c and insulin). Serum concentration of non cholesterol sterols (sitosterol, campesterol, stigmasterol, desmosterol and lanosterol) and oxysterols (24S-hydroxycholesterol, 27-hydroxycholesterol and 7α-hydroxycholestenone) were measured by High Performance Liquid Chromatography tandem Mass Spectrometry in these subjects throughout along the study in order to demonstrate the effect of different red meat on the hepatic metabolism of cholesterol.