Diet, Healthy Clinical Trial
Official title:
Studying the Impact of a Low Carbohydrate Diet on the Small Intestinal Microbiota
The investigators will recruit probands with a ileo- or colostoma that are otherwise in good general health and analyse the stomal fluids for their microbiota composition. Sampling will be performed over a time span of 28 days, after 14 days probands will modify their base-line diet to a low carbohydrate diet.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | March 2024 |
Est. primary completion date | March 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Ileostomy or colostomy - Good general health - Written informed consent Exclusion Criteria: - Major metabolic diseases that prevent adherence to low carbohydrate diet - Participation in other clinical trial interfering with study protocol |
Country | Name | City | State |
---|---|---|---|
Switzerland | Inselspital | Bern |
Lead Sponsor | Collaborator |
---|---|
Insel Gruppe AG, University Hospital Bern |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assessment of microbiota profile by 16S sequencing before and after diet modification for significant differences | Sample content will be measured by 16S sequencing, ecological distances will be assessed by beta-diversity | 28 days | |
Secondary | Relative changes of total metabolite abundance in urine | The whole metabolite composition will be assessed by an untargeted screen done with mass spectrometry | 28 days | |
Secondary | Analysis of microbiota metabolic potential (microbiome DNA coding for enzymes) after shotgun sequencing | The total DNA content of the samples will be annotated for for known metabolic active enzymes to assess functionality | 28 days | |
Secondary | Analysis of microbiota biomass | The samples will be analysed for the number of bacteria present in them | 28 days | |
Secondary | Changes of further metagenomic microbiome composition (viral, eucaryotic DNA) | The DNA of the samples will be screened for parts belonging to viruses or eucaryotic cells | 28 days | |
Secondary | Culturing of microbiota if appropriate (in vitro) | If of interest, culturing of specific bacterial strains will be attempted in vitro with the aim to recreate in vivo observations | 28 days |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06111040 -
Nurturing Needs Study: Parenting Food Motivated Children
|
N/A | |
Completed |
NCT06299072 -
A Cross-sectional Online Survey Among Saudi Arabian Population in the Age Group 18-40 Years to Assess Whole Grain (WG) Awareness, Consumption Levels, and Dietary Habits Around Breakfast
|
||
Recruiting |
NCT05863559 -
Super Chef - an Online Program Promoting the Mediterranean Dietary Pattern to Lower Income Families
|
N/A | |
Active, not recruiting |
NCT04583683 -
Effects of Very Low Calorie Diet vs Metabolic Surgery on Weight Loss and Obesity Comorbidities
|
N/A | |
Not yet recruiting |
NCT05934968 -
Mad Dog Cooking Class Series: Effects on Dietary Self-efficacy, Eating Behaviors and Health Outcomes
|
N/A | |
Not yet recruiting |
NCT05783141 -
Prebiotic Effects in Healthy Toddlers
|
N/A | |
Active, not recruiting |
NCT05544461 -
Piloting a Web-based Personalised Nutrition App (eNutri) With UK University Students
|
N/A | |
Active, not recruiting |
NCT04991142 -
Models of Nutrition From Continuous Glucose Monitors
|
||
Recruiting |
NCT04946448 -
COmbinAtion Therapy of dieT With biologicalS for Crohn's Disease: the OATS Study
|
N/A | |
Not yet recruiting |
NCT06464497 -
Whole Foods for Teens: A Pilot Dietary Intervention to Reduce Body Adiposity in Adolescents With Obesity
|
N/A | |
Completed |
NCT04084028 -
Cooking as a Health Behavior in College Students
|
N/A | |
Terminated |
NCT04067362 -
Chicory Fiber Effect on Satiety and GI Tolerance
|
N/A | |
Recruiting |
NCT05512247 -
Hearty Meals for Mom- Pilot Study of Meal Delivery for Cardiometabolic Health During Pregnancy
|
N/A | |
Recruiting |
NCT06145009 -
Time Restricted Eating, Eating Behaviors, and Cardiometabolic Risk in Emerging Adult Women
|
N/A | |
Recruiting |
NCT06022302 -
Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism
|
N/A | |
Completed |
NCT05173376 -
SEP and the Impact of Portion Size on Daily Energy Intake
|
N/A | |
Recruiting |
NCT04374747 -
Fruit and Vegetable Intervention in Lactating Women to Reduce Breast Cancer Risk
|
N/A | |
Recruiting |
NCT04876053 -
Home Food Delivery for Diabetes Management in Patients of Rural Clinics
|
N/A | |
Not yet recruiting |
NCT06298253 -
Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2
|
N/A | |
Not yet recruiting |
NCT05566587 -
Designing a Personalized Diet to Reduce the Risk of Crohn's Disease Onset
|
N/A |