Diet Habit Clinical Trial
Official title:
Mixed Plant- vs. Animal-based Supplementary Protein to Support Muscle Adaptations to Resistance Exercise: a Randomized Clinical Trial
This is a randomized controlled trial aimed to investigate the effects of different supplementary protein sources on muscle adaptations to resistance exercise. Young, healthy, recreationally active participants consuming an omnivorous diet with protein intake within recommended dietary allowance (RDA) (i.e.; 0.8-1.0 g.kg-1. d-1) will be recruited to undergo a 12-wk supervised resistance training program in combination with the intake of three 15-g daily doses (45g. d-1 total) of either a mixed plant- (i.e.; soy and pea protein) or animal-based (i.e.; whey protein) protein in drink form as a supplementary source of protein to their main meals of the day (i.e.; breakfast, lunch, and dinner). Before (PRE) and after (POST) the 12-wk intervention, participants will be assessed for body composition by dual-energy X-ray absorptiometry (DXA), muscle cross-sectional area (ultrasound) and fiber cross-sectional area (muscle biopsy), and maximal isotonic strength (1RM). Training consists of a resistance training (RT) program individually supervised by a researcher blinded to treatment in a laboratorial setting. Assessments will also be conducted in a blinded fashion.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | March 1, 2025 |
Est. primary completion date | March 1, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - Physically active (according to the International Physical Activity Questionnaire (IPAQ) - Absence of any chronic condition that could preclude participation in a RT program or physical testing - Habitual protein consumption within RDA = 0.8 =1.0 g.kg-1. d-1 Exclusion Criteria: - Prior history of anabolic steroids use, current or previous (= 3 m) - Use of ergogenic or protein-based supplements, current or previous (< 1 y) - Engagement in energy-restricted diets |
Country | Name | City | State |
---|---|---|---|
Brazil | University of Sao Paulo | São Paulo |
Lead Sponsor | Collaborator |
---|---|
University of Sao Paulo General Hospital | NotCo Brasil Distribuicao e Comercio de Produtos Alimenticios LTDA |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | vastus lateralis muscle cross sectional area | the investigators used ultrasound measures of the vastus lateralis cross sectional area as the primary outcome | Ultrasound images will be obtained both at baseline (before the comencement of the study) and immediately after the 12-week intervention period | |
Secondary | lean mass | total body and lower limb lean mass assessed by DXA | DXA scans will be taken both at baseline (before the comencement of the study) and immediately after the 12-week intervention period | |
Secondary | fiber cross sectional area | vastus lateralis fiber cross sectional area from muscle biopsy samples | Fiber cross sectional areas will be measured both at baseline (before the comencement of the study) and immediately after the 12-week intervention period | |
Secondary | maximal isotonic strength | lower-limb maximal isotonic strength will be assessed in the leg-press exercise by means of the one-repetition-maximum test (1-RM test) | 1-RM tests will be taken both at baseline (before the comencement of the study) and immediately after the 12-week intervention period |
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