Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia — TOTAL

Diaphragmatic Hernia Clinical Trial

Official title:
Randomized Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) Versus Expectant Management During Pregnancy in Fetuses With Left Sided and Isolated Congenital Diaphragma Hernia and Severe Pulmonary Hypoplasia.

Status Completed

Clinical Trial Summary

This trial investigates whether prenatal intervention improves survival rate of fetuses with isolated congenital diaphragmatic hernia and severe pulmonary hypoplasia, as compared to expectant management during pregnancy, both followed by standardized postnatal care.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01240057
Study type	Interventional
Source	University Hospital, Gasthuisberg
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	November 2011
Completion date	December 2020

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT00966823` - Fetal Tracheal Balloon Study in Diaphragmatic Hernia	Phase 2
Completed	`NCT00371241` - Antibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO
Completed	`NCT04716166` - Incentive Spirometry and Upper Abdominal Laparoscopic Surgery	N/A
Not yet recruiting	`NCT05354505` - Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)	N/A
Completed	`NCT02466451` - Study in Children With the Diagnosis of Congenital Diaphragmatic Hernia (CDH) and Oesophageal Atresia (EA)	N/A
Recruiting	`NCT00373438` - Fetoscopic Tracheal Balloon Occlusion in Left Diaphragmatic Hernia	Phase 2
Withdrawn	`NCT00373763` - Fetoscopic Tracheal Balloon Occlusion in Unborns With Severe Congenital Diaphragmatic Hernia - EUROTRIAL I	N/A
Terminated	`NCT02364843` - A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months	N/A