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Defining the Normal Range for Maximal Sniff Diaphragm Thickening Fraction — SNIFF II  

Diaphragm Clinical Trial

Official title:
Defining the Normal Range for Maximal Sniff Diaphragm Thickening Fraction

Clinical Trial Summary

This study is investigating the normal range of maximal diaphragm thickness during a sniff inspiratory manoeuvre using ultrasound in healthy subjects stratified by age and gender.

Clinical Trial Description

Diaphragm dysfunction is associated with poor clinical outcomes in critically ill patients but is difficult to diagnose. Traditionally, diaphragm function is measured by evaluating inspiratory muscle strength via maximal inspiratory pressure (MIP). However, this technique relies on a volitional maximal effort and can be challenging for patients to perform.

An alternative to measuring inspiratory muscle strength is the sniff inspiratory pressure approach. During short, sharp sniffs, the diaphragm is maximally activated.

Currently, there are no reported values of the normal range of maximal diaphragm thickness during a sniff maneuver. This study will define the normal range of values for sniff maximal diaphragm thickening fraction, maximal thickening against an occluded airway, and diaphragm thickening during resting tidal breathing in healthy subjects. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03129386
Study type Observational
Source University Health Network, Toronto
Contact
Status Completed
Phase
Start date June 8, 2016
Completion date January 2019
View Details
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