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Diaphragm Defect clinical trials

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NCT ID: NCT04118725 Completed - Systemic Sclerosis Clinical Trials

Muscular Respiratory Involvement and Systemic Sclerosis

SIROCO
Start date: October 21, 2019
Phase: N/A
Study type: Interventional

Dyspnea in systemic sclerosis (ScS) constitute a major factor of functional disability. Intensity of dyspnea is sometimes discordant with objectives data from cardiopulmonary involvements, suggesting unknown additional factors. Diffuse fibrosing myopathy of bad prognosis have been reported in ScS.To now, muscular respiratory involvement has not been evaluated in ScS. Therefore, ScS patients (with or without dyspnea) could have underlying respiratory muscular involvement not detected by current standard of care with pulmonary function tests (PFT). This project is the first, to the best of our knowledge, to assess frequency of respiratory muscular involvement in ScS and to evaluate a screening strategy of this involvement.