Diaper Dermatitis Clinical Trial
Official title:
Evaluation of Factors Affecting Diaper Dermatitis
Diaper dermatitis is one of the most common skin problems in infants and children.It is a
skin disorder in the perineal , perianal and surrounding area .It frequently occurs also in
areas immediately adjacent to the diaper area .
Diaper dermatitis is caused by lack of fresh air,dampness and irritation.With prevelance from
7-35 % in newborns.This skin disorder typically develops between nine and twelve months of
age .
The development of diaper dermatitis is multifactorial . Newborn skin exhibits a cutaneous
immaturity and an increased susceptibility toward skin barrier disruption or percutaneous
absorption.
The epidermal barrier function resides in the outermost epidermal layer , the stratum corneum
, which is the region of terminal skin differnatiation and is composed of corneocytes . The
hydrophobic components of the lipid matrix provide the epidermal permeability barrier and
protect against excessive water loss and irritant penetration , whereas the corneocytes and
the cornified envelope provide mechanical strength to the stratum corneum.
The skin in the diaper area is predisposed to irritation by the prolonged contact with
irritants , such as urine and feces as well as by diaper occlusion, with leads to an increase
in hydration and skin ph. Overhydration promotes degradation of "the brick and mortar"
structure of stratum corneum, contributing to impraired barrier function.
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