Photon Counting Detector CT Image Quality

Diagnostic Imaging Clinical Trial

Official title: Image Quality and Diagnostic Accuracy of Photon Counting Computed Tomography of the Upper and Lower Extremity

Status Not yet recruiting

Clinical Trial Summary

This study aims to compare subjective image quality and diagnostic accuracy of a photon counting detector computed tomography (PCD-CT) scanner compared with an energy integrating detector (EID)-CT scanner as the reference standard.

Clinical Trial Description

Computed tomography (CT) imaging plays a key role in diagnostic radiology, and is particularly valuable in assessing a myriad of musculoskeletal conditions (e.g. trauma, degenerative disorders, post-surgical follow-up, inflammatory diseases). The vast majority of today's CT scanners are equipped with an energy-integrating detector (EID), which converts energy of incoming X-ray photons in a two-step process into electric signals: First, scintillators generate visible light, which in turn is converted to the electric signal by photodiodes. Recently, photon-counting detector computed tomography (PCD-CT) scanners became commercially available and have been introduced to improve imaging performance through direct transformation of X-ray photons into electron hole pairs upon absorption in a semiconductor layer, generating an electrical signal proportional to the photon energy. Current literature has shown that PCD-CT can offer higher spatial resolution, increased contrast-to-noise ratio, higher dose-efficiency, and inherent multi-spectral imaging capacity. Moreover, the results from cadaver studies suggest that PCD-CT can preserve image quality with reduced radiation dose. However, data on the diagnostic accuracy of PCD-CT compared to EID-CT is currently limited in the field of musculoskeletal radiology. In addition to conventional CT acquisition, multi-spectral CT imaging in patients with gout and after trauma, is used in clinical routine to delineate materials with a specific absorption coefficient: in gout, urate crystals can be visualized, while after trauma, bone marrow edema can be detected. For EID-CT, different techniques for multi-spectral CT imaging are available (e.g. fast kV switching, dual source CT) which are widely used in clinical routine. Multi-spectral imaging is also inherently available for recently introduced PCD-CT. However, data on diagnostic accuracy of multi-spectral PCD-CT is currently lacking. ;

Related Conditions & MeSH terms

• Diagnostic Imaging

• NCT number: NCT06281808
• Study type: Interventional
• Source: Balgrist University Hospital
• Contact: Reto Sutter, MD
• Phone: 0041443861111
• Email: reto.sutter@balgrist.ch
• Status: Not yet recruiting
• Phase: N/A
• Start date: February 28, 2024
• Completion date: December 31, 2026