Analysis of Risk Factors of Diabetic Retinopathy

Status Not yet recruiting

Clinical Trial Summary

The aim of the study is to analyse the risk factors involved in the development of diabetic retinopathy.

Clinical Trial Description

Introduction Worldwide, diabetic retinopathy (DR) is the leading cause of blindness among working age adults [1] Diabetes mellitus (diabetes) is a group of conditions in which elevation and dysregulation of blood glucose levels result from either decreased production of insulin or systemic resistance to insulin's effects. Economic costs of diabetes in the. U.S. in 2012. Diabetes Care. 2013;36(4):1033-46. Insulin resistance, which often precedes type 2 diabetes, is a component of the metabolic syndrome. Those with diabetes are more likely to have other components of the metabolic syndrome including abdominal obesity, dyslipidemia, hypertension, prothrombotic state, and a proinflammatory state [2] Third Report of the National Cholesterol Education Program. (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143-421 Another key point for the development of vascular lesions is the capillary basement membrane thickening as a result of hyperglycemia, increased synthesis of basement membrane components and other factors. This thickening of the basement membrane is related to excess vascular permeability that leads to leaky vessels, compromised tight-junctions and increased vesicular transport [3] Although major risk factors-hyperglycemia and hypertension-are extensively studied and show a strong association with DR Some studies indicate that prolonged DM duration is indeed a well-established risk factor for DR [4-5]. Regarding microalbuminuria, studies report its association as a marker of microvascular dysfunction and DR [6-7], however further studies are needed to confirm this relationship [6]. Other risk factors such as body mass index (BMI) show controversies in relation to its association with this disease [8]. The aim of this study was to investigate risk factors for DR. Diabetic retinopathy is the leading cause of blindness in adults living in developed countries.9 Almost all patients with type 1 diabetes mellitus (DM) and more than 60% of patients with type 2 DM will develop some degree of retinopathy after a 20-year history of diabetes.10 It has also been well established that DM increases the risk of cardiovascular disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06154746
Study type	Observational
Source	Assiut University
Contact	dalia asem, Bachelor's degree
Phone	01033343611
Email	daliaasem8@gmail.com
Status	Not yet recruiting
Phase
Start date	June 2024
Completion date	June 2025

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.