Diabetic Retinopathy Clinical Trial
Official title:
A 24-Month Cohort Study Assessing the Nature and the Time Course of Structural and Functional Changes to the Retina Following PASCAL Photocoagulation in Proliferative Diabetic Retinopathy Patients
Laser therapy is an established method to stabilize and control proliferative diabetic eye disease. Questions on the long-term effect on the retina from these treatments remain to be answered. The purpose of the study was to evaluate changes in the retina following panretinal photocoagulation (PRP) over time, using structural and functional diagnostic tests.
Diabetic retinopathy is the most common cause of adult-acquired retinal vascular disease.
Diabetic retinopathy is estimated to affect more than 100 million adults, and is the leading
cause of blindness worldwide.
Over the past 30 years, epidemiological studies and clinical trials have shown that early
detection through annual eye exams, intensive glucose and blood pressure control, and timely
laser photocoagulation could prevent visual loss. More recently, a variety of newer ocular
treatments and medications have been introduced, such as the use of the PASCAL
photocoagulation laser system, and various anti-vascular endothelial growth factor therapies.
While these treatments have revolutionized how diabetic retinopathy patients are managed
clinically, questions on appropriate patient selection and the long-term efficacy and safety
of these treatments remain to be answered.
The purpose of this study is to focus on studying the nature and the time course over 2 years
of structural and functional changes to the retina following PASCAL photocoagulation in
severe preproliferative or proliferative diabetic retinopathy patients.
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