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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01255293
Other study ID # MAR-3
Secondary ID
Status Completed
Phase N/A
First received December 6, 2010
Last updated June 13, 2013
Start date November 2010
Est. completion date October 2012

Study information

Verified date June 2013
Source Mid Atlantic Retina
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

The purpose of this study is to assess the retinal redetachment rates with 1000 centistoke versus 5000 centistoke silicone oil tamponade for repair of complex retinal detachments.


Description:

As part of retinal detachment surgery, the eye is typically filled with a gas bubble or silicone oil bubble. This bubble acts like a balloon inside the eye and helps to keep the retina pushed back against the eye wall so it can heal in its proper place. Gas bubbles spontaneously dissolve over a few weeks whereas silicone oil remains in the eye until removed with another surgery. When retinal detachments are associated with significant scar tissue on the retinal surface, silicone oil is often used since it can remain filling the eyeball for as long as necessary to help the retina to heal properly in place. Currently, two different types of silicone oil (1000 centistoke and 5000 centistoke) are commercially available and have been approved for use in the eye by the Food and Drug Administration. The goal of the study is to compare the outcomes using these two different types of silicone oil.

The retinal detachment will be repaired in a standard fashion. There will be no difference between the way retinal detachments are repaired in this study compared to those not in this study. Patients will be randomly assigned (like a flip of a coin) to receive one of the types of silicone oil. Both types of oil have very similar characteristics. The primary difference is that one type is thicker (more viscous) than the other, analogous to honey in comparison with maple syrup.


Recruitment information / eligibility

Status Completed
Enrollment 15
Est. completion date October 2012
Est. primary completion date October 2012
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- Presence of rhegmatogenous retinal detachment or tractional retinal detachment due to grade C or worse proliferative vitreoretinopathy or proliferative diabetic retinopathy.

- Judgment by the investigator that silicone oil tamponade is surgically indicated for appropriate repair of the complex retinal detachment.

- Visual acuity of light perception or better.

- Ability to provide written informed consent and comply with study assessments for the full duration of the study.

Exclusion Criteria:

- Inability to re-attach the retina at the time of surgery.

- Prior trabeculectomy or tube shunt surgery.

- Corneal opacity which limits visualization of the trabecular meshwork.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment


Intervention

Procedure:
1000 centistoke silicone oil
Patients who are enrolled in the study and have been identified to have a complex retinal detachment requiring silicone oil tamponade may be randomly assigned to receive 1000 centistoke silicone oil.
5000 centistoke silicone oil
Patients who are enrolled in the study and have been identified to have a complex retinal detachment requiring silicone oil tamponade may be randomly assigned to receive 5000 centistoke silicone oil

Locations

Country Name City State
United States Wills Eye Institute Philadelphia Pennsylvania

Sponsors (1)

Lead Sponsor Collaborator
Mid Atlantic Retina

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Retinal redetachment rate Six months No
Secondary Best-corrected visual acuity 6 and 12 months No
Secondary Silicone oil emulsification rate Gonioscopy examination will be used at monthly postoperative visits to assess silicone oil emulsification in each patient. Monthly No
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