Epicardial Adipose Tissue and Arterial Stiffness in People Living With Diabetes (METAB-CV-PWV)

Diabetic Patients Clinical Trial

— METAB-CV-PWV  

Official title:

Tissu Adipeux épicardique et rigidité artérielle Chez Les Personnes Vivant Avec un diabète

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05681533
• Other study ID #: APHP220876
• Status: Recruiting
• Start date: March 31, 2021
• Est. completion date: March 2023

Study information

• Verified date: November 2022
• Source: Assistance Publique - Hôpitaux de Paris
• Contact: Emmanuel COSSON, Pr
• Phone: 01 48 95 51 54
• Email: emmanuel.cosson[@]aphp.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The present study is a retrospective and prospective current care cohort that will allow us to evaluate the relationship between epicardial fat volume and increased arterial stiffness in a person living with diabetes.

Description:

Epicardial adipose tissue is considered as the cardiac visceral fat and is associated with increased cardiovascular risk, for example in diabetes. Thus, the mechanisms involved seem to be related to myocardial lipotoxicity; atherosclerosis in connection with inflammation and secretion of proinflammatory factors such as cytokines but also insulin resistance.

In this context, the investigators hypothesize that epicardiac adipose tissue volume will be higher in patients with increased arterial stiffness than in those without. In this study, the investigators will then try to verify the existence of a relationship between pericardial adipose tissue volume and increased arterial stiffness in people living with diabetes.

To do this, the investigators will analyze the results of measurements of pericardial fat volume, coronary calcium score, and pulse wave velocity in diabetic patients.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 400
• Est. completion date: March 2023
• Est. primary completion date: February 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

Patients will be eligible for participation in the study if:

• They are informed and have not objected to participating in the research.

• They have type 1 or 2 diabetes.

• They perform a coronary calcium score measurement by CT scan and a pulse wave velocity assessment during their routine care practice.

Related Conditions & MeSH terms

• Diabetic Patients

Intervention

Procedure:
• CT scan
coronary calcium score measurement by CT scan

Locations

Country	Name	City	State
France	endocrinologie site, Avicenne hospital	Bobigny

Sponsors (1)

Lead Sponsor	Collaborator
Assistance Publique - Hôpitaux de Paris

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Epicardial fat volume	Epicardial fat volume will be determined using cardiac CT scan without contrast injection.	the inclusion visit