Diabetic Neuropathy Clinical Trial
Official title:
The Efficacy and Safety of Peripheral Mobilized Mononuclear Cell-based Therapy in Patients With Diabetic Painful Neuropathy
To investigate the efficacy and safety of autologous peripheral blood stem cell based therapy in patients with diabetic painful neuropathy.
Diabetic painful neuropathy a prevalent, disabling disorder. Currently, the only effective
treatments are glucose control and pain management. Diabetic neuropathy is characterized by
reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic
factors. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells
have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem
or progenitor cells contain various angiogenic and neurotrophic factors, these cells have
been attempted for treating experimental diabetic neuropathy, and turned out to be effective
for reversing various manifestations of experimental diabetic neuropathy.
However, stem-cell therapy was not proven in human study. Therefore, we will investigate the
efficacy and safety of autologous peripheral blood stem cell injection in diabetic
neuropathy.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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