Diabetic Nephropathy Clinical Trial
Official title:
To Compare the Efficacy and Safety of TW vs Valsartan in the DN
The purpose of this study is to compare the efficacy and safety of Tripterygium (TW) versus Valsartan (ARB) in the Diabetic Nephropathy (DN).
Diabetic nephropathy with heavy proteinuria have high risks of progressing to end stage
renal disease. Though recent studies have shown that ACEI or ARB could reduce proteinuria of
DN and slowed the progression to ESRD. But ARBs can only reduce proteinuria about 30%, so
some patients still have heavy proteinuria,and then loss their renal function rapidly. So,
to reduce the proteinuria of DN is a very important therapy target.
Tripterygium (TW) is a Chinese traditional patent drug, it can reduce proteinuria of chronic
glomerular nephritis. So, we designed this randomized, prospective clinical trial to assess
the efficacy and safety of TW versus ARB in the treatment of heavy proteinuria of DN.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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