Diabetic Nephropathies Clinical Trial
Official title:
Comparative Effects of add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on Serum NT-PRO BNP and Proteinuria in Type 2 Diabetics With Nephropathy
This study was designed to assess the efficacy of adding pentoxifylline to losartan in comparison with increasing dose of losartan in type 2 diabetes patients with nephropathy. also the effect of pentoxifylline on N terminal brain natriuretic peptide (NT-pro BNP) and C-reactive protein
Addition of pentoxifylline to losartan provides antiproteinuric effects in type 2 diabetes
patients with nephropathy that might relate to its effect on N terminal brain natriuretic
peptide (NT-pro BNP) and C-reactive protein.
Pentoxifylline is a phosphodiestrase inhibitor with anti-inflammatory effects that was used
in type 2 diabetes patients with nephropathy for treatment of diabetes complications.
NT-Pro BNP, which is released from the heart due to wall stress and pressures, is known as a
diagnostic and prognostic marker for heart failure and cardiovascular mortality in type 2
diabetes.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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