Diabetic Macular Edema Clinical Trial
Official title:
The Influence of Retinal Oxygenation on the Clinical Outcomes in Eyes With Different Vitreoretinal Pathologies After a Successful Vitrectomy
Vitrectomy is the common treatment for patients with macular edema secondary to epiretinal
membrane. Recently, in eyes with diabetic macular edema or persistent macular edema following
retinal vein occlusion, vitrectomy will be increasingly performed as an additional treatment
modality. In eyes with impaired oxygen situation vitrectomy may improve the retinal oxygen
saturation. However, little information is available about the oxygenation and the blood flow
of the retinal vessels after vitroretinal surgery.
Hypoxia is a the major trigger of vascular endothelial growth factor (VEGF), which is in turn
the most important factor for the development of macular edema. It is a major issue to
improve the oxygen situation and the blood flow of the retina and there are just a few not
satisfactory procedures available to overcome this problem. However, vitrectomy would be an
adequate therapy for many of these diseases, and it would be an appreciated side effect of
the treatment in almost every case.
To investigate the influence of oxygenation and blood flow of the retina on clinical outcomes
after a successfully 23 gauge vitrectomy in eyes with epiretinal membrane, persistent macular
edema following diabetic retinopathy or retinal vein occlusion.
n/a
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