Evaluate the Role of Soleus Muscle Exercise in Glycaemic Control in Diabetic Kidney Disease Patients

Diabetic Kidney Disease Clinical Trial

Official title:

Evaluate the Role of Soleus Muscle Exercise in Glycaemic Control in Diabetic Kidney Disease Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06120569
• Other study ID #: Soleus ms exercise in diabetis
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 18, 2024
• Est. completion date: October 2024

Study information

• Verified date: November 2023
• Source: Assiut University
• Contact: Nora Kamal, Resident
• Phone: 01002380242
• Email: norahussein097[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Evaluate the role of Soleus muscle exercise in management diabetic kidney disease

Description:

management of diabetic kidney disease. To enhance their glycemic control, diabetic patients are advised to perform 150 minutes per week of moderate-to-vigorous aerobic activity Diabetic patients with regular physical activity have reduced daily insulin dose with more glycemic control. In addition to glycemic control, it has also been postulated that the addition of brief intervals of high intensity, sprint -type exercise to aerobic exercise can decrease the risk of late nocturnal hypoglycemic episodes Marc T. Hamilton et al., 2022, reported that the human soleus muscle could raise local oxidative metabolism to high levels for hours without fatigue, during a type of soleus-dominant activity while sitting (soleus push up exercise), even in unfit volunteers. They reported that soleus push up exercise can improve systemic VLDL-triglyceride and glucose homeostasis by a large magnitude, e.g., 52% less postprandial glucose excursion (∼50 mg/dL less between ∼1 and 2 h) with 60% less hyperinsulinemia. Muscle biopsies revealed there was minimal glycogen use. This can be explained that the soleus doesn't rely completely on intramuscular glycogen, Instead, it uses a mixture of fuels from glucose and lipoproteins.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 45
• Est. completion date: October 2024
• Est. primary completion date: October 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patients age 18-60 yrs.,

• patients with Diabetic kidney disease, not on dialysis

• with stabilized diabetic treatment regimen for 3 months before participating in the study

Exclusion Criteria:

• advanced osteoarthritis of lower limb joints

• advanced poly neuropathic patients

• CKD type V on dialysis

• Diabetic Foot

• hemophilia

• bleeding tendency

• AKI

• other causes of chronic kidney disease

• patients refuse to participate in the study

Related Conditions & MeSH terms

• Diabetic Kidney Disease
• Diabetic Nephropathies
• Kidney Diseases

Intervention

Device:
• Soleus ms exercise
Soleus muscle exercise before and after eating by half an hour

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Nora Hussein Kamal

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	HbA1C less than 7%	Improve HbA1c by soleus muscle exercise	One year
Secondary	ratio of albumin (mcg/L) to creatinine (mg/L)ratio	Improve alb /creatinine ratio	One year

External Links

•   Pudmed