Diabetic Gastroparesis Clinical Trial
Official title:
Transcutaneous Electroacupuncture for Gastroparesis
Gastroparesis is a common disease defined as delayed emptying of the stomach. It is present
in at least 20% of about 150 million patients with diabetes worldwide and in more than 20%
of patients with functional dyspepsia that affects about 10%-25% of the general population.
Gastroparesis is a refractory disease with a lack of therapeutic options. Common symptoms of
gastroparesis include nausea, vomiting, early satiety and abdominal bloating.
Electroacupuncture (EA) is a combined procedure with acupuncture and electrical current
stimulation instead of manual manipulations of the needles. Recent studies in our lab with
EA or transcutaneous EA (TEA) have suggested a therapeutic role of EA or TEA for gastric
motility disorders. Improvement has been observed with EA or TEA in gastric emptying as well
as dyspeptic symptoms. In this project, a micro-stimulator is designed and developed for the
TEA therapy. The micro-stimulator is small enough so that it can be attached to the skin
next to the stimulation electrodes and therefore the patient can resume normal daily
activity while being treated by TEA. This is not only attractive but also more effective
since TEA can be performed more often and for longer durations.
This exploratory project is designed to study the feasibility, efficacy and certain
mechanisms of the proposed method of "wireless" TEA in patients with gastroparesis. Firstly
the feasibility of the chronic use the proposed micro-stimulator will be studied. Secondly,
the efficacy of the TEA in improving delayed gastric emptying and symptoms of gastroparesis
will be investigated in a double-blinded crossover design in patients with diabetic or
idiopathic gastroparesis. Thirdly, possible mechanisms involving pathogeneses of
gastroparesis with TEA will be investigated.
n/a
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