Safety Study of Topical Human FGF-1 for Wound Healing

Status Not yet recruiting

Clinical Trial Summary

The purpose of the study is to see if FGF-1 is safe when applied topically to the surface of a wound.

Clinical Trial Description

Dermal ulcers pose a significant healthcare problem in the United States, ultimately affecting 10-15% of the approximately 20 million patients with diabetes and a similar number of patients with chronic venous insufficiency. Dermal leg and foot ulcers can result from compromised arterial inflow, microvascular perfusion or venous outflow which can lead to amputation unless vascular perfusion is improved. FGF-1 for topical administration offers the possibility of improved microvascular perfusion by promoting the formation of new blood vessels in the wound bed resulting in enhanced development of granulation tissue and accelerated healing. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00916292
Study type	Interventional
Source	Phage Pharmaceuticals, Inc.
Contact
Status	Not yet recruiting
Phase	Phase 1
Start date	November 2012
Completion date	September 2013

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02652754` - Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Diabetic Foot Ulcers	Phase 1
Completed	`NCT01070433` - A Clinical Study of the Safety and Efficacy of MEBO Wound Ointment in Subjects With Diabetic Foot Ulcers	Phase 2
Completed	`NCT00971048` - Evaluation of the Effects of HP828-101 Versus Standard of Care in the Management of Partial or Full Thickness Wounds	N/A
Terminated	`NCT00762138` - The AutoloGel™ Post-Market Surveillance (TAPS) Program	N/A
Completed	`NCT00578604` - Non-Invasive Assessment of Wound Healing With Optical Methods	N/A
Completed	`NCT05417425` - Omeza Products in Combination With Standard of Care for the Treatment of Diabetic Foot Ulcers	Phase 1
Completed	`NCT02631512` - Evaluation of Woulgan in Diabetic Foot Ulcer	Phase 4
Terminated	`NCT01816633` - Effectiveness of AutoloGel Therapy in Diabetic Foot Ulcers	N/A
Completed	`NCT02222376` - Effect of Topic Pirfenidone in Diabetic Ulcers	Phase 3
Completed	`NCT01454401` - LeucoPatch™ Study A Multicenter Study on the Effect of LeucoPatch™ in Diabetic Foot Ulcers	N/A
Completed	`NCT01221207` - Instant Total Contact Cast to Heal Diabetic Foot Ulcers	N/A
Withdrawn	`NCT01105884` - Clinical and Cost Effectiveness of Different Dressing Materials in Diabetic Foot Ulcers	N/A
Completed	`NCT01291160` - Transdermal Continuous Oxygen Therapy for Diabetic Foot Ulcers	Phase 2/Phase 3
Completed	`NCT00536744` - Effectiveness of dermaPACE™ Device and Standard Treatment Compared to Standard Treatment Alone for Diabetic Foot Ulcers	Phase 3
Terminated	`NCT00316537` - Safety and Preliminary Efficacy Study of Nicotine Gel to Treat Diabetic Foot Ulcers	Phase 1/Phase 2
Completed	`NCT00013299` - Clinical Trials of Footwear in Patients With Diabetes-Study Arm 2,3	Phase 2
Completed	`NCT00013286` - A Prospective Study of Endothelial Dysfunction and Diabetic Foot Ulcer Risk	Phase 2
Terminated	`NCT02667327` - A Study of Granexin Gel in the Treatment of Diabetic Foot Ulcer	Phase 3
Completed	`NCT01154374` - A Clinical Study of the Safety and Efficacy of MEBO® Wound Ointment in Subjects With Diabetic Foot Ulcers (Pilot)	Phase 2
Not yet recruiting	`NCT02672280` - Safety and Exploratory Efficacy Study of Collagen Membrane With Mesenchymal Stem Cells in the Treatment of Skin Defects	Phase 1/Phase 2