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NCT05825378 Clinical Trial

The Effect of Intercostal Nerve Block With Dexamethasone and Ropivacaine on Rebound Pain After Thoracoscopic Surgery

Dexamethasone Clinical Trial

Official title:
The Effect of Intercostal Nerve Block With Dexamethasone and Ropivacaine on Rebound Pain After Thoracoscopic Surgery: a Randomized, Double-blind, Controlled Study

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05825378
Other study ID # 20230411
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date May 1, 2023
Est. completion date August 6, 2025

Study information
Verified date April 2023
Source Beijing Tiantan Hospital
Contact Ruquan Han, M.D., PhD.
Phone 8610-59976660
Email ruquan.han@ccmu.edu.cn
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Regional nerve block is one of the commonly used methods for postoperative analgesia after thoracoscopic surgery. Recent studies have found that rebound pain may occur after regional block, which is defined as acute postoperative pain that occurs after the resolution of sensory block related to regional anesthesia, and seriously affects the quality of postoperative recovery of patients. There is evidence that rebound tenderness is associated with local anesthetic toxicity and proinflammatory effects. The aim of this study was to investigate the effect of dexamethasone on rebound pain after a single intercostal nerve block in patients undergoing thoracoscopic surgery.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 260
Est. completion date August 6, 2025
Est. primary completion date May 5, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patients scheduled for elective thoracoscopic surgery Age > 18 years old ASA ?-? Informed consent was signed Exclusion Criteria: - Patients with aoagulation disorders Patients with allergy to local anesthetics Patients with severe cardiopulmonary diseases Patients had systemic steroid use Patients with chronic pain Patients with uncontrolled diabetes and mental disorders History of drug abuse; Body Mass Index more than 35 kg.m-2 Pregnant or breastfeeding woman.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Dexamethasone 8mg+0.375% ropivacaine
Ultrasound-guided intercostal nerve block was performed on the surgical side, and 3 to 5ml of a mixture of 0.375% ropivacaine and 8 mg dexamethasone was injected at each point
• 0.375% ropivacaine
Ultrasound-guided intercostal nerve block was performed on the surgical side, and 3 to 5ml 0.375% ropivacaine was injected at each point

Locations
Country Name City State
China Beijing Tiantan Hospital, Capital Medical University Beijing

Sponsors (1)
Lead Sponsor Collaborator
Beijing Tiantan Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary The incidence of rebound pain after the disappearance of nerve block effect NRS < 3 in PACU and NRS > 7 after the disappearance of nerve block effect 8 hours after the nerve block
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