Autism Clinical Trial
Official title:
Magnetic Resonance Imaging in Children and Adolescents With Autism and Multiple Complex Developmental Disorders
This study aims to investigate the overlap and differences between autism and MCDD as neuropsychiatric childhood disorders. MRI scans are acquired from subjects with autism, subjects with a diagnosis of MCDD and typically developing controls. Volumetric measure of various brain regions are compared between groups. We hypothesize that subjects with autism will have larger brains than controls, whereas subjects with MCDD will have smaller brains.
Autism and Childhood-onset Schizophrenia have been clearly defined as neuropsychiatric
disorders since the studies of Kolvin and Rutter. In the early seventies the discussion on a
possible overlap between the two types of disorders vanished, but nowadays this issue
revives. Amongst all the advances of the DSM diagnostic criteria, the omission of
developmental information appears to be a disadvantage. The Pervasive Developmental Spectrum
is a broad spectrum, that with exceptions for Autism and some other characteristic
disorders, to a large extent consists of an ill-defined restcategory. Most patients actually
belong to this last category , the so-called PDD-NOS group. In recent years more has been
published about the subgroups within this large group. One of these subgroups, the Multiple
Complex Developmental Disorder (MCDD), appears to be a well defined category of patients
whose validity has been confirmed by research. In adulthood, a large percentage of this MCDD
group seems to develop Schizophrenia or a Schizophrenia related disorder. This again does
arise the question of a possible overlap. This discussion is even emphasized by reports
notably on -mostly retrospective- studies of premorbid autistic features in patients with
Schizophrenia.
In the present day studies on neurodevelopmental psychiatric disorders, there is a search
for biological markers or discriminating factors. One of the applied methods is structural
imaging. Question marks can be placed on the differing study set-ups and protocols which
seriously hinder their inter alia comparison. However one can still conclude that the
results of studies on subjects with Autism and Childhood-onset Schizophrenia reveal major
differences. However, structural abnormalities do not tell anything about possible
functional abnormalities. But detecting structural abnormalities can be helpful in forming
hypothesis about the origin of these neurodevelopmental disorders.
In this study brain structures will be measured by magnetic resonance imaging. Structural
deviances will be interpreted as a reflection of functional abnormalities. It is
hypothesized that the abnormalities on structural imaging in MCDD patients will more
resemble the abnormalities found in the literature for (Childhood-onset) Schizophrenia
instead of the deviances revealed in subjects with Autism.
In this study patients with Autism and MCDD will be divided in two groups: before and after
puberty. Each group will behold 15-40 subjects. They each will be compared with two groups
of 20-25 age, sex and IQ matched controls. They will participate in carrying out a MRI scan,
filling in some questionnaires and if necessary an IQ test and a general physical
examination.The MRI scans will be measured, and compared with each other in order to find
‘disorder-specific’ abnormalities.
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05302167 -
Molehill Mountain Feasibility Study.
|
N/A | |
Completed |
NCT04167839 -
Effects of Sensory Diets on Children's Sensory Processing Skills, Psychosocial Skills, and Classroom Engagement
|
N/A | |
Terminated |
NCT04049981 -
Investigation of Mechanisms of Action in Superpower Glass
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT06080087 -
Implementation Toolkit to Enhance EBP Among Marginalized Families
|
N/A | |
Recruiting |
NCT04107064 -
Achieving Steady Work Among Adults With Autism Through Specialized Employment Program
|
N/A | |
Completed |
NCT03206996 -
Exposure Therapy for Auditory Sensitivity in Autism
|
N/A | |
Completed |
NCT01914393 -
Pediatric Open-Label Extension Study
|
Phase 3 | |
Completed |
NCT05588570 -
Coaching Children With Anxiety and Autism Through Telehealth
|
N/A | |
Enrolling by invitation |
NCT06058104 -
Evaluating Efficacy of a Digital Game Therapeutic for Children With Autism
|
N/A | |
Completed |
NCT02847182 -
Cord Blood Infusion for Children With Autism Spectrum Disorder
|
Phase 2 | |
Withdrawn |
NCT02414451 -
Trial of Propranolol in Adults and Adolescents With ASD and Predictors of Response
|
N/A | |
Completed |
NCT03002363 -
The Effects of Video Modeling of Audiological Testing on Pediatric Patient Compliance
|
Phase 1 | |
Completed |
NCT02911194 -
a2 Milk for Autism and Attention-deficit Hyperactivity Disorder (ADHD)
|
N/A | |
Completed |
NCT02720900 -
Prebiotic Intervention for Autism Spectrum Disorders
|
N/A | |
Completed |
NCT02536365 -
Sensory Integration Therapy in Autism: Mechanisms and Effectiveness
|
N/A | |
Completed |
NCT02708290 -
Mental Imagery Therapy for Autism (MITA) - an Early Intervention Computerized Language Training Program for Children With ASD
|
||
Completed |
NCT02508922 -
Trial of Vitamin D3 Supplementation in Paediatric Autism
|
N/A | |
Recruiting |
NCT01836562 -
A Clinical Trial to Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Autism
|
Phase 1/Phase 2 | |
Recruiting |
NCT02255565 -
Dose Response Effects of Quillivant XR in Children With ADHD and Autism: A Pilot Study
|
Phase 4 | |
Completed |
NCT02154828 -
Clinical Evaluation of Integrative Practices Units Infant and Child Care for Unit Children With Typical or Atypical Autism (AUTISM)
|