Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT03542539 |
| Other study ID # |
RODIPSL |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
August 1, 2018 |
| Est. completion date |
December 1, 2019 |
Study information
| Verified date |
May 2018 |
| Source |
Assiut University |
| Contact |
Doaa Abou-Taleb, lecturer |
| Phone |
01001463937 |
| Email |
doddaabou_taleb[@]yahoo.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Dermoscopy is a non-invasive method that allows evaluation of colors and microstructures of
the epidermis, the dermoepidermal junction, and the papillary dermis not visible to the naked
eye. These structures are specifically correlated to histologic features. The identification
of specific diagnostic patterns related to the distribution of colors and dermoscopy
structures can better suggest a malignant or benign pigmented skin lesion. The use of this
technique provides a valuable aid in diagnosing pigmented skin lesions
Description:
Skin color affected by many agents as it is determined by several chromophores such as
melanin, hemoglobin and carotenoids. Among these, melanin is the main one responsible for
different skin colors.
Melanin is produced by special skin cells called melanocytes and packed in organelles called
melanosomes. Sometimes, human skin may present a non-uniform melanin distribution in two
different ways, leading to pigmentary disorders.
In the first, melanin concentration increases to levels above normal resulting in
hypermelanosis. In the second, the melanin concentration decreases to levels below normal,
resulting in hypomelanosis.melanogenesis is acomplex process when disturbed ,it results into
various pigmentary disorders either hypo or hyper pigmentation.
These disorders may be congenital or acquired, permenant or temporary, systemic or region
restricted).
Pigmentary disorders are include alarge number of heterogenous conditions that are usually
characterized by altered melanocyte density, melanin concentration, or both, and result in
altered pigmentation of the skin. Some of these disorders are extremely common such as
(melisma and vitiligo), whereas others are rare
Differential Diagnosis of Hyper and Hypopigmentation:
Hyperpigmentation Hypopigmentation Postinflammatory hyperpigmentation (acne, psoriasis,
atopic and contact dermatitis, lichen planus, trauma, drugs, and fixed-drug eruptions)
Melasma Solar lentigines Ephelides (freckles) Café-au-lait macules Nevi Melanoma and
precursors Acquired (common) Vitiligo Pityriasis alba Tinea versicolor Postinflammatory
hypopigmentation Congenital (uncommon) Albinism Piebaldism Tuberous sclerosis Hypomelanosis
of Ito
Several studies have shown that dermoscopy may come in very handy for assisting the
noninvasive diagnosis of various general dermatological disorders, including scalp/hair
diseases (trichoscopy) , nail/nailfold abnormalities (onychoscopy) , cutaneous
infections/infestations (entomodermoscopy) and inflammatory dermatoses (inflammoscopy) .
Dermoscopy is a non-invasive method that allows evaluation of colors and microstructures of
the epidermis, the dermoepidermal junction, and the papillary dermis not visible to the naked
eye. These structures are specifically correlated to histologic features. The identification
of specific diagnostic patterns related to the distribution of colors and dermoscopy
structures can better suggest a malignant or benign pigmented skin lesion. The use of this
technique provides a valuable aid in diagnosing pigmented skin lesions, This traditionally
consists of a magnifier , a non-polarised light source, a transparent plate and a liquid
medium between the instrument and the skin .
The increasing use of dermoscopy in general dermatology can be partially explained by
commercially available new generations of handheld dermoscopes, which are small enough to be
easily placed in every dermatologist's pocket . It is a safe and rapid diagnostic tool that
assists in clinical examination and management decision in dermatology
