3T Therapy in the Treatment of MDA5-positive Dermatomyositis

Status Enrolling by invitation

Clinical Trial Summary

The goal of this clinical trial is to learn if a combination of tacrolimus, tafocitinib and thalidomide (3T therapy) works to treat severe MDA5 positive dermatomyositis in adults. It will also learn about the safety of 3T therapy. The main questions it aims to answer are: Does 3T therapy prolong the overall survival time of MDA5 positive dermatomyositis? What medical problems do participants have when taking 3T therapy? Participants will: Take 3T therapy every day for 12 months Visit the clinic once every 2 weeks for checkups and tests

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Dermatomyositis

Clinical Trial Details

NCT number	NCT06438679
Study type	Interventional
Source	Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact
Status	Enrolling by invitation
Phase	Phase 4
Start date	March 19, 2024
Completion date	December 2026

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05833711` - Study Evaluating Efficacy and Safety of Froniglutide (PF1801) in Patients With Idiopathic Inflammatory Myopathy	Phase 2
Not yet recruiting	`NCT06284954` - A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis	Phase 2
Completed	`NCT01906372` - Acthar in Treatment of Refractory Dermatomyositis and Polymyositis	Phase 2
Completed	`NCT01813617` - Outcome in Patients With Recent Onset Polymyositis and Dermatomyositis	N/A
Completed	`NCT01165008` - Anakinra in Myositis	Phase 2/Phase 3
Completed	`NCT00004357` - Absorption of Corticosteroids in Children With Juvenile Dermatomyositis	Phase 2
Recruiting	`NCT05832034` - Add-on Intravenous Immunoglobulins in Early Myositis	Phase 2
Recruiting	`NCT05979441` - A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy	Phase 3
Not yet recruiting	`NCT05027152` - Muscle Function and Effects of Repetitive Task Training in Patients With Inflammatory Myopaties	N/A
Active, not recruiting	`NCT04723303` - Phase 1 Study of ULSC in Patients With Polymyositis (PM) and Dermatomyositis (DM)	Early Phase 1
Completed	`NCT03267277` - Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis	Phase 2/Phase 3
Recruiting	`NCT05437263` - A Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Dermatomyositis	Phase 3
Active, not recruiting	`NCT04044690` - A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of IgPro20 in Adults With Dermatomyositis (DM)	Phase 3
Recruiting	`NCT05523167` - A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.	Phase 2/Phase 3
Not yet recruiting	`NCT06004817` - Evaluation of Severity in Juvenile and Adult-onset Dermatomyositis
Recruiting	`NCT03324152` - Effects of High-intensity Interval Training (HIIT) in Recent Onset Polymyositis and Dermatomyositis	N/A
Completed	`NCT02043548` - Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis	Phase 2
Completed	`NCT03414086` - Predictor of Clinical Response to Acthar in Myositis
Completed	`NCT04628936` - Open-label Extension to the Phase 2 Crossover Study (PRESIDIO) Evaluating KZR-616 in Patients With PM and DM.	Phase 2
Recruiting	`NCT03293615` - Exercise Capacity of Patients With Dermatomyosis	N/A