Plexin D1 as a Potential Biomarker inPM/DM

Status Not yet recruiting

Clinical Trial Summary

evaluation of level of serum circulating plexin D1 on extacellular vesicles in adult PM/DM patients and juvenile dermatomysitis.

Clinical Trial Description

Polymyositis (PM) and dermatomyositis (DM) are autoimmune inflammatory diseases that primarily target muscle. autoimmune Dermatomyositis (DM) is a rare inflammatory disease that mainly affects skin, muscle, and lung. Inflammatory myopathies (IMs) often have distinct histopathologic features suggesting humorally mediated involvement of the microcirculation in dermatomyositis (DM), including early capillary deposition of the complement C5b-9 membranolytic attack complex (MAC) and secondary ischaemic changes; and CD8 T-cell-mediated and MHC1-restricted autoimmune attack of myofibers in polymyositis (PM) and inclusion body myositis. Plexins are a conserved family of large proteins (~200kDa) that are the canonical receptors for semaphorin molecules. Plexins are divided into four classes, A through D. Recently, plexin and semaphorin molecules have been shown to control cell movement and cell-cell interaction in the immune system . Extracellular vesicles (EVs) are lipid bilayer membrane vesicles that exist in various bodily fluids. EVs are released by normal, diseased, and transformed cells in vitro and in vivo and are capable of carrying lipids, proteins, mRNAs, non-coding RNAs, and even DNA. They are abundant in serum and plasma and have been a source of considerable interest as potential disease biomarkers. Normally, they maintain physiological functions by transferring biological information to neighboring cells and facilitating intercellular communication, but are also involved in the pathogenesis of numerous autoimmune diseases LC/MS analysis identified 1220 proteins in serum EVs. Of these, plexin D1 was enriched in those from PM/DM patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05637931
Study type	Observational
Source	Assiut University
Contact	Reham Khalifa Ali Khalifa, doctor
Phone	+201023152733
Email	Rehamkhalefa96@gmail.com
Status	Not yet recruiting
Phase
Start date	December 25, 2022
Completion date	January 25, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05833711` - Study Evaluating Efficacy and Safety of Froniglutide (PF1801) in Patients With Idiopathic Inflammatory Myopathy	Phase 2
Not yet recruiting	`NCT06284954` - A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis	Phase 2
Completed	`NCT01906372` - Acthar in Treatment of Refractory Dermatomyositis and Polymyositis	Phase 2
Completed	`NCT01813617` - Outcome in Patients With Recent Onset Polymyositis and Dermatomyositis	N/A
Completed	`NCT01165008` - Anakinra in Myositis	Phase 2/Phase 3
Completed	`NCT00004357` - Absorption of Corticosteroids in Children With Juvenile Dermatomyositis	Phase 2
Recruiting	`NCT05832034` - Add-on Intravenous Immunoglobulins in Early Myositis	Phase 2
Recruiting	`NCT05979441` - A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy	Phase 3
Not yet recruiting	`NCT05027152` - Muscle Function and Effects of Repetitive Task Training in Patients With Inflammatory Myopaties	N/A
Active, not recruiting	`NCT04723303` - Phase 1 Study of ULSC in Patients With Polymyositis (PM) and Dermatomyositis (DM)	Early Phase 1
Completed	`NCT03267277` - Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis	Phase 2/Phase 3
Recruiting	`NCT05437263` - A Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Dermatomyositis	Phase 3
Active, not recruiting	`NCT04044690` - A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of IgPro20 in Adults With Dermatomyositis (DM)	Phase 3
Recruiting	`NCT05523167` - A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.	Phase 2/Phase 3
Not yet recruiting	`NCT06004817` - Evaluation of Severity in Juvenile and Adult-onset Dermatomyositis
Recruiting	`NCT03324152` - Effects of High-intensity Interval Training (HIIT) in Recent Onset Polymyositis and Dermatomyositis	N/A
Completed	`NCT02043548` - Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis	Phase 2
Completed	`NCT03414086` - Predictor of Clinical Response to Acthar in Myositis
Completed	`NCT04628936` - Open-label Extension to the Phase 2 Crossover Study (PRESIDIO) Evaluating KZR-616 in Patients With PM and DM.	Phase 2
Recruiting	`NCT03293615` - Exercise Capacity of Patients With Dermatomyosis	N/A