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Dermatitis clinical trials

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NCT ID: NCT03568071 Terminated - Atopic Dermatitis Clinical Trials

A Study to Assess Efficacy, Safety, Tolerability and Pharmacokinetics (PK)/Pharmacodynamics (PD) of MOR106 in Subjects With Moderate to Severe Atopic Dermatitis

IGUANA
Start date: April 26, 2018
Phase: Phase 2
Study type: Interventional

This is a Phase II, randomized, double-blind, placebo-controlled multicenter study of repeated doses of MOR106 administered as IV infusion. MOR106, is an antibody which is being developed as a treatment for diseases such as psoriasis and atopic dermatitis. An antibody is a protein that is made by the body in a defense reaction against viruses and bacteria or other small particles. In this case, MOR106 will act against IL-17C interleukin by binding to it. This way it could be possible to act against these diseases.

NCT ID: NCT03559270 Terminated - Atopic Dermatitis Clinical Trials

A Study of Baricitinib (LY3009104) in Participants With Moderate to Severe Atopic Dermatitis

BREEZE-AD6
Start date: June 27, 2018
Phase: Phase 3
Study type: Interventional

This open-label study will evaluate the long-term efficacy and safety of baricitinib in adult participants with moderate to severe atopic dermatitis (AD).

NCT ID: NCT03540160 Terminated - Psoriasis Clinical Trials

Study of the Long Term Safety of Serlopitant for the Treatment of Pruritus (Itch)

Start date: March 15, 2018
Phase: Phase 3
Study type: Interventional

Study of the long term safety of serlopitant for the treatment of pruritus in adults.

NCT ID: NCT03539601 Terminated - Atopic Dermatitis Clinical Trials

A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD

Start date: April 27, 2018
Phase: Phase 4
Study type: Interventional

This 4-week study will evaluate the safety and efficacy of crisaborole ointment 2%; crisaborole vehicle; topical corticosteroid and topical calcineurin inhibitor, applied twice daily (BID) in subjects who are at least 2 years of age with mild-moderate AD. A Sub-Study of Optical Coherence Tomography and Biomarkers in Subjects ages 2 to <18 years old, with Mild to Moderate Atopic Dermatitis, treated with Crisaborole Ointment, 2% or Crisaborole Vehicle Ointment or Hydrocortisone Butyrate 0.1% Cream applied BID will also be conducted at select sites.

NCT ID: NCT03517566 Terminated - Atopic Dermatitis Clinical Trials

A Study to Assess the Safety and Efficacy of ZPL389 in Patients With Moderate to Severe Atopic Dermatitis

Start date: November 14, 2018
Phase: Phase 2
Study type: Interventional

This was a randomized, double-blind, placebo-controlled, parallel-group study to assess safety and efficacy of ZPL389 in subjects with moderate to severe atopic dermatitis with a total study duration up to 24 weeks

NCT ID: NCT03411837 Terminated - Atopic Dermatitis Clinical Trials

Dupilumab Phase 4 Study

DRS
Start date: October 16, 2017
Phase:
Study type: Observational

The investigators will monitor for the incidence of adverse-events in a prospective, longitudinal, non-interventional and observational real-world sub-study of adults patients with moderate-to-severe AD who are receiving dupilumab as standard-of-care therapy.

NCT ID: NCT03395132 Terminated - Clinical trials for Infected Atopic Dermatitis/Eczema

Efficacy and Safety of Fucicort® Lipid Cream Compared to Combination Treatment With Fucidin® Cream Followed by Betamethasone (Lianbang Beisong®) Cream and Fucicort® Lipid Cream Vehicle in Clinically Infected Atopic Dermatitis/Eczema

Start date: July 31, 2018
Phase: Phase 3
Study type: Interventional

The trial is designed to compare the efficacy and safety of Fucicort® Lipid cream with the combination treatment of Fucidin® cream followed by betamethasone (Lianbang Beisong®) cream, or Fucicort® Lipid cream vehicle, when applied twice daily for two weeks. The trial is designed to demonstrate that treatment with Fucicort® Lipid cream is not inferior to the combination treatment with the mono component drugs, Fucidin® cream followed by betamethasone (Lianbang Beisong®) cream and that treatment with Fucicort® Lipid cream is superior to the treatment with Fucicort® Lipid cream vehicle. This is a 3-arm, parallel group, active- and vehicle-controlled trial comparing the efficacy and safety after 14 days treatment of Fucicort® Lipid cream, to Fucidin® cream followed by betamethasone (Lianbang Beisong®) cream, or Fucicort® Lipid cream vehicle, in subjects with clinically infected AD/eczema.

NCT ID: NCT03389893 Terminated - Clinical trials for Atopic Dermatitis (AD)

Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis

Start date: July 25, 2018
Phase: Phase 4
Study type: Interventional

The purpose of this study is to understand the effect that T helper 2 (Th2) blockade has on well-described pathophysiological features of Atopic Dermatitis (AD), for example: barrier, epidermal activation, dysbiosis and epidermal lipids.

NCT ID: NCT03298113 Terminated - Clinical trials for Incontinence-associated Dermatitis

Comparative Study to Assess an Advanced Skin Protectant in the Management of Incontinence-associated Dermatitis

Start date: November 17, 2017
Phase: N/A
Study type: Interventional

The purpose of the clinical study is to assess the effects of 3M Cavilon Advanced Skin Protectant in comparison to different local IAD care regimes in hospitals (IAD: Incontinence-associated Dermatitis)

NCT ID: NCT03245385 Terminated - Atopic Dermatitis Clinical Trials

Multiple-Dose Pharmacokinetics and Potential for Adrenal Suppression Following Treatment With Halobetasol Spray in Patients With Atopic Dermatitis

Start date: July 24, 2017
Phase: Phase 2
Study type: Interventional

This is an open-label, safety study designed to assess the multiple-dose pharmacokinetics and potential for adrenal suppression following topical treatment with halobetasol propionate 0.05% spray applied twice-daily in adult patients with moderate to severe atopic dermatitis. At least 40 eligible patients with atopic dermatitis that satisfy all eligibility criteria will be enrolled into the study