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NCT02929043 Clinical Trial

Psychophysical Characterization and Brain Correlates of Dentine Hypersensitivity

Dentine Hypersensitivity Clinical Trial

Official title:
Psychophysical Characterization and Brain Correlates of Dentine Hypersensitivity

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02929043
Other study ID # G1
Secondary ID
Status Completed
Phase N/A
First received January 8, 2016
Last updated October 25, 2017
Start date July 2015
Est. completion date June 30, 2017

Study information
Verified date October 2017
Source University of Zurich
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Up to date, devices capable of delivering controlled, calibrated, non-contact cold air stimuli in a MR environment are unavailable for quantitative sensory testing. This project therefore aimed at designing and constructing a novel MR-compatible, computer-controlled cold air stimulation device that produces air puffs in a broad flow and cold temperature range. By means of this device, detailed psychophysically testing and subsequent brain scanning of dentine hypersensitivity (DH) subjects will be possible to gain new insights about DH mechanisms.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date June 30, 2017
Est. primary completion date April 30, 2016
Accepts healthy volunteers No
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

- Age and between 18 - 60

Exclusion Criteria:

- Caries

- Defective restorations

- Full crowns

- Orthodontic bands

- Bleeding on probing and periodontal pockets deeper than 3 mm

- Subjects with gross periodontal disease or treatment of periodontal disease in the past 12 months.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• air puffs

Locations
Country Name City State
Switzerland University of Zurich, Center of Dental Medicine Zurich

Sponsors (2)
Lead Sponsor Collaborator
University of Zurich GlaxoSmithKline

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Subjective ratings using the BORG scale individual subject perception ratings will be recorded by means of an adapted BORG scale. For reliability, intraclass correlations will be used covering 3-4 measures within a 3-4-weeks period. May 1, 2016
Primary blood oxygenation level dependent (BOLD) response Changes in blood oxygenation level (indirect measure of neural activity) will be recorded October 1, 2016
See also
  Status Clinical Trial Phase
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Completed NCT01115452 - Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity Phase 2
Completed NCT02931734 - Assessment of Different Protocols for Cervical Dentin Hypersensitivity Treatment N/A
Recruiting NCT03177109 - Comparison of Different Desensitizers in Reducing Dentinal Hypersensitivity Phase 3
Completed NCT06197555 - Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes N/A
Completed NCT01724008 - The Efficacy of a Dentifrice in Providing Relief From Dentinal Hypersensitivity Phase 3
Completed NCT01592864 - The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity Phase 3
Recruiting NCT03076944 - Evaluation of Desensitization Protocols in Reduction of Dentin Hypersensitivity N/A
Recruiting NCT03083496 - Clinical Evaluation of Different Potassium Oxalate Concentrations in Dentin Hypersensitivity Treatment N/A
Completed NCT03072719 - The Efficacy of a Dentifrice in Providing Relief From Immediate and Short Term Relief From Dentinal Hypersensitivity Phase 3
Completed NCT03515902 - The Effects of Mouthguard and Desensitizing Toothpaste in Reducing Dental Hypersensitivity N/A
Completed NCT04754763 - A Comparative Study On The Effect Of Propolis And Dentine Bonding Agent In Treating Dentine Hypersensitivity Early Phase 1
Completed NCT04005417 - Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity
Not yet recruiting NCT04179994 - Efficacy of Miswak Extract Toothpaste as Compared Potassium Nitrate in The Management of Dentinal Hypersensitivity N/A
Completed NCT01827670 - Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity Phase 3
Recruiting NCT05392868 - Managing Dentine Hypersensitivity With Silver Diamine Fluoride on Older Adults Phase 2
Completed NCT01075256 - Dose Response of a Tubule Occlusion Agent Phase 4
Completed NCT01691560 - Exploratory Study to Evaluate an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity Phase 2
Completed NCT02018783 - Single Application of Desensitizing Pastes as Dentin Sensitivity Treatment N/A
Completed NCT01592851 - Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity Phase 3