Dental Pulp Regeneration Clinical Trial
Official title:
Dental Pulp Regeneration for Root Canals by Autologous Tissue Transplantation
The purpose of this study is to develop new improved therapy for teeth that require root canals due to tooth infection or tooth inflammation. Investigators will recruit total of 50 participants from the age group 7 - 50 at the UCLA School of Dentistry Endodontic clinic. The participants will be divided into two groups, one will receive traditional therapy, which may include root canal or a procedure called "revascularization," which is a procedure trying to regrow the tissue inside the tooth. The other group of participants will receive the test treatment, which will involve harvesting of pulp tissues from the same tooth or other teeth that are planned for extraction. Investigators will prepare these tissues and place the tissues back into the cleaned root canal space with induced bleeding to allow regrowth of the tissue. For all participants, investigators will follow up after 6, 12, and 24 months in a shorter appointment, which may involve taking x-ray and clinical exam.
The goal of the study is to test whether autologous pulpal mesenchymal stem cells (MSCs) is capable of de novo regeneration of pulp-dentin complex and restoration of normal pulp physiology in teeth with necrotic or inflamed pulp. This is a highly novel study that will bring the regenerative endodontic approaches to the next level. Furthermore, revascularization approaches, as delivered in today's endodontic offices, present several challenges, including lack of de novo pulp-dentin regeneration, and frequent occurrence of intracanal calcification. These findings attest to the limitation of revascularization as a regenerative endodontic procedure (REP) and necessitates advent of novel approach for functional restoration of dental pulp. The ultimate objective of the current study is to develop a new REP that allows for de novo regeneration of functional dental pulp, which can be readily performed in a chair-side manner. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02842515 -
Feasibility of the Preparation of an Advanced Therapy Medicinal Product for Dental Pulp Regeneration
|
N/A | |
| Completed |
NCT04190914 -
Different Treatment Modality in Necrotic Primary Molars
|
N/A | |
| Withdrawn |
NCT01805388 -
Comparison of Tissue in Regenerative Endodontic Procedures and Apexification
|
Phase 1 | |
| Completed |
NCT00595595 -
Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth
|
N/A |