Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth

Dental Pulp Diseases Clinical Trial

Official title:

Development of a Model to Evaluate Regenerative Endodontic Techniques

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00595595
• Other study ID #: HSC20070149H
• Status: Completed
• Phase: N/A
• First received: January 7, 2008
• Last updated: September 14, 2012
• Start date: February 2007
• Est. completion date: September 2012

Study information

• Verified date: September 2012
• Source: The University of Texas Health Science Center at San Antonio
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue in order to revitalize teeth.

Description:

The long term goal of this research project is to develop a method to regenerate dental pulp-like tissue as an alternative method to conventional root canal treatment. The objective of this study is to identify the methods necessary to regenerate dental pulp-like tissue in human teeth. We will collect small (~4X4mm) pieces of oral mucosa that are normally removed during surgical tooth extractions, isolate human postnatal progenitor/stem cells and, using an in vitro cell culture system, combined isolated cells with various scaffolds and test compounds to determine optimal conditions to differentiate pulp-like tissue (eg, odontoblasts, fibroblasts, endothelium, etc) grown in segments of human roots.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1080
• Est. completion date: September 2012
• Est. primary completion date: September 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 16 Years to 65 Years

Eligibility

Inclusion Criteria:

• Pre-existing indication for surgical extraction of impacted teeth

• Age 16-65

Exclusion Criteria:

• Ages less than 16 or over 65

• No pre-existing indication for surgical extraction of impacted teeth

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Dental Pulp Diseases
• Dental Pulp Regeneration

Locations

Country	Name	City	State
United States	The University of Texas Health Science Center at San Antonio	San Antonio	Texas

Sponsors (1)

Lead Sponsor	Collaborator
The University of Texas Health Science Center at San Antonio

Country where clinical trial is conducted

United States,