Dental Fluorosis Clinical Trial
Official title:
Evaluation of Degree of Enamel Fluorosis in Children of Tobruk and Kufra Regions in Libya
Fluorosis is caused by hypomineralization in the enamel due to increased fluoride ingestion during early childhood (Cawson.1, Wong et al. 2, and Sudhir 3). A considerable amount of evidence has been reported over the years, which has shown that presence of fluoride ions at up to one part per million in public water supply has reduced the prevalence of teeth decayed with minimal chance of dental fluorosis. The WHO recognized these facts by its resolution in 1969 4 and 1975 5, which stated that water fluoridation, where applicable, should be the cornerstone of any national policy of caries prevention
The optimal concentration is defined as that which gives maximal protection against dental
caries, with minimal clinically observable dental fluorosis (Dunning 7). This level is
determined according to the climate and the resultant drinking habits (Newborn 6). Cawson 1
stated that mottling of enamel is the most frequently seen and most reliable sign of
excessive quantities of fluoride in the drinking water. Dean 8 concluded that a fluoride
level of above 1ppm does not significantly reduce caries beyond the optimal effect of 1ppm.
Different classifications have been introduce to score dental fluorosis. (Dean 9, Al -Alousi
10, Thylstrup & Fejerskov 11, (Fejerskov, 12). and the DDE index by FDI 1982). Aira Sabokseir
13, concluded, fluorosis indices, if used alone, could result in misdiagnosis of dental
fluorosis and information about adverse health-related conditions linked to DDEs
(Developmental Defects of Enamel) at specific positions on teeth could help to differentiate
between genuine fluorosis and fluorosis-resembling defects.Various figures for mouth
prevalence of enamel fluorosis have been reported by different investigators. 39.2% by
Al-Alousi 10, for Welsh children, 32% by Akpata 14 for Nigerian children. Using the DDE index
of the FDI (1982), Al alousi 10 defective enamel of 48.9% in children from south Wales. In
England,Tabari 15 found the prevalence of fluorosis was 54% in the fluoridated area and 23%
in the fluoride-deficient area. In Iran the prevalence of fluorosis was 61% (Azami-Aghdash et
al., 16).
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05051748 -
Clinical Evaluation of Different Minimal Invasive Treatment Modalities of Mild to Moderate Dental Fluorosis Using A Visual Analog Scale
|
N/A | |
| Completed |
NCT05204277 -
Clinical Evaluation of Dental Fluororsis Treatment Modalities
|
N/A | |
| Completed |
NCT01049503 -
Effect of pH and Fluoride Concentration of Dentifrices on Caries Control
|
Phase 3 | |
| Completed |
NCT01978041 -
Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water
|
Phase 1 | |
| Completed |
NCT01571050 -
Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as Abrasives
|
Phase 1 | |
| Completed |
NCT01589991 -
Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes
|
Phase 1 |