Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth

Dental Extraction Clinical Trial

Official title:

Does Articaine, Rather Than Prilocaine, Increase the Success Rate of Anaesthesia for Extraction of Maxillary Teeth

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04236115
• Other study ID #: Taibah dental College
• Status: Completed
• Phase: Phase 4
• Start date: September 20, 2017
• Est. completion date: June 20, 2018

Study information

• Verified date: January 2020
• Source: Taibah University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Ninety-five patients, aged between 16 and 70 years old, were included in this study. Patients were divided into two groups. Group one received Articaine 4% with 1:00.000 Adrenalines. Group two received Prilocaine with 3% Felypressin (0.03 I.U. per ml). Onset time of anaesthesia was objectively evaluated by using electronic pulp testing.

Description:

85 patients in this study had successful local anaesthetic followed by extraction within the study duration time (10 minutes). However, there were six patients with failure anaesthesia (5 in prilocaine group and 1 in articaine group). By application Person's Chi-square test (x2), there were no significant differences in the number of the episodes of the anaesthetic success between articaine and prilocaine groups at time intervals (P-value = 0.5). T- test showed there have been no important variations within the mean onset time of anaesthesia for articaine and prilocaine buccal infiltrations (P-value =0.1).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 95
• Est. completion date: June 20, 2018
• Est. primary completion date: April 20, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients have one or two upper teeth for extraction, subject tooth or its adjacent must be vital, healthy patient or patient with mild systemic diseases (class I or II according to American Society of Anesthesiology).

Exclusion Criteria:

• Patients excluded from this study if they have allergy to local anaesthetic agents or need surgical, or multiple teeth extraction.

Related Conditions & MeSH terms

• Dental Extraction
• Maxillary Teeth
• Overcoming the Failure of Anaesthesia

Intervention

Drug:
• Articaine 4%
Articaine 4% is dental local anaesthetic agent
• Prilocain 3%
prilocaine is dental local anaesthetic agent
• Adrenalin
adrenaline is a vasoconstrictor
• Felypressin
Felypressin is a vasoconstrictor

Locations

Country	Name	City	State
Saudi Arabia	Taibah University	Medina

Sponsors (1)

Lead Sponsor	Collaborator
Taibah University

Country where clinical trial is conducted

Saudi Arabia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Does articaine, rather than prilocaine, increase the success rate of anaesthesia for extraction of maxillary teeth	to compare the anaesthetic performances of 3% prilocaine (the safest local anaesthetic) with 4 % articaine (the local anaesthetic with fastest onset time of action) when used for maxillary teeth extraction	6 months