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Effect of Smoking on Saliva Composition and the Development of Dental Erosion

Dental Erosion Clinical Trial

Official title:
Effect of Smoking on Saliva Composition and the Development of Dental Erosion - an In-situ Study

Clinical Trial Summary

The aim of this study is to investigate whether smoking is associated with changes in salivary composition and/or predisposition to erosion. Healthy volunteers are observationally wearing an intraoral device with both bovine tooth specimens (enamel and dentin) and resin specimens twice for two hours each. Afterwards, specimens are eroded extraorally and calcium release into the acid is measured. Total protein concentration and protein composition of the salivary pellicles on the resin samples are measured. Additionally, salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, total protein content and protein composition as well as concentration of inorganic calcium, phosphate, and fluoride) are measured.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04208802
Study type Observational
Source University of Göttingen
Contact
Status Completed
Phase
Start date September 24, 2020
Completion date July 29, 2022
View Details
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