Evaluation of Antimicrobial Efficacy of Green Tea, Garlic With Lime, Pomegranate Extract and Chlorhexidine Mouth Rinses in a Group of Egyptian Children (In-Vivo Study)

Dental Caries Clinical Trial

Official title:

Evaluation of Antimicrobial Efficacy of Green Tea, Garlic With Lime, Pomegranate Extract and Chlorhexidine Mouth Rinses in a Group of Egyptian Children (In-Vivo Study)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05841589
• Other study ID #: PED18-8M
• Status: Completed
• Phase: N/A
• Start date: February 21, 2018
• Est. completion date: December 1, 2021

Study information

• Verified date: April 2023
• Source: Ain Shams University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

the aim of the clinical trial is to evaluate the antimicrobial efficacy of the herbal mouth rinses against chlorhexidine mouth rinse.

Description:

The present study was carried out on 84 children. Children were recruited based on certain inclusion criteria after signing a written informed consent by their parents. They were divided into 4 groups. Group (I) the children rinsed with Chlorhexidine mouth rinse, the child rinsed for 1 minute and plaque samples were collected from the child before and after rinsing. Group (II) children rinsed with green tea extract, while group (III) children rinsed with garlic with lime extract and group (IV) the children rinsed with pomegranate extract mouth rinse with the same procedures. .child satisfaction was measured using 5-point pictorial likert scale which is graded from 1 to 5 (1.Excellent.2.Good.3 Average 4.Poor. 5. Very poor).

All the plaque samples were collected and put in sterile test tubes containing thioglycolate as a transport media. They transferred to the microbiology laboratory within half an hour after rinsing for detection of bacterial counts. These samples were incubated 48-96 hours at 37°C. Number of bacterial colonies were counted by hand-held digital colony counter.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 84
• Est. completion date: December 1, 2021
• Est. primary completion date: November 30, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 5 Years to 8 Years

Eligibility

Inclusion Criteria:• Age 5-8 years.

• No history of systemic disease.

• Patients didn't received antibiotics for at least 3 months before and during the study

Exclusion Criteria:• Children who can't expectorate completely or brush their teeth on their own.

• Fixed or removable orthodontic appliances.

• Children with intra oral abscess, oral lesions or gingival diseases.

• Parental consent was not acquired

Related Conditions & MeSH terms

• Dental Caries

Intervention

Procedure:
• Green tea extract mouth rinse
herbal extracts mouth rinse that was prepared in the microbiology laboratory
• Garlic with lime extract mouth rinse
herbal extracts mouth rinse that was prepared in the microbiology laboratory
• Pomegranate extract mouth rinse
herbal extracts mouth rinse that was prepared in the microbiology laboratory
• Chlorhexidine mouth rinse
herbal extracts mouth rinse that was prepared in the microbiology laboratory

Locations

Country	Name	City	State
Egypt	Ain Shmas University	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
omnia sayed

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	patient satisfaction	Child satisfaction was measured using a 5-point pictorial likert scale .This Facial image scale was suitable and easy way to evaluate patient satisfaction about taste, smell and willing to use the mouth rinse. Its format was graded from 1 to 5 while 1 is the most satisfied and 5 is the least satisfied	Through study completion, an average of 1 month
Secondary	bacterial count	counting of Colony forming units was done by hand- held digital colony counter	1 day after rinsing