The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Dental Caries Clinical Trial

Official title:

The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04136639
• Other study ID #: REC17-082
• Status: Completed
• Phase: N/A
• Start date: June 1, 2019
• Est. completion date: October 1, 2019

Study information

• Verified date: October 2019
• Source: Al-Azhar University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Prevention of dental caries has taken a great importance in the last decade. The use of herbal and natural products became mandatory to avoid the side effects of commercially available medications. Aim of the study; the aim was to investigate the anti-cariogenic effect of miswak and grape seed extract (GSE).

Description:

Patients used Miswak sticks, grape seed extract mouth wash and fluoride mouthwash twice daily for three month. Saliva samples were collected at base line and after one month and three month. Assessment of bacterial count and saliva buffering capacity were performed at base line and after one and three month.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: October 1, 2019
• Est. primary completion date: August 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 50 Years

Eligibility

Inclusion Criteria:

• Patients with high caries risk

• Males or females

• Medically free patients

• Patients approving to participate in the study

Exclusion Criteria:

• Patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination

• Patients had history of professional cleaning in the last 15 days

• Patients with exposed pulp

• Evidence of parafunctional habits

• Patients with developmental dental anomalies

• Patients undergoing or will start orthodontic treatment

• Patients with removable prosthesis

• Periapical Abscess or Fistula

Related Conditions & MeSH terms

• Dental Caries

Intervention

Other:
• Miswak
sticks
• Grape Seed Extract Mouthwash
Mouthwash
• fluoride
mouthwash

Locations

Country	Name	City	State
Egypt	Al Azhar University	Cairo	Nasr City

Sponsors (1)

Lead Sponsor	Collaborator
Al-Azhar University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	quantitative measure of the change in salivary streptococcus mutans Count from baseline to one month and three months.	the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline,after one month and after three months. Every time samples were incubated with Mitiis Salivaris with Bacitricin and 20% sucrose for streptococcus mutans count.	Baseline, one month, three months.
Secondary	quantitative measure of the change in saliva buffering capacity from baseline to one month and three months.	the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline, after one month and after three months. each time, saliva buffering capacity was measured using Hand Held pH meter and 0.1 mol/l hydrochloric acid that was titrated to the tested saliva.	baseline, one month , three months