Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid

Dental Caries Clinical Trial

Official title:

Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid Using Chair Side(Potential of Hydrogen) pH Meter Assessment Method in Adult Population: Randomized Clinical Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03143023
• Other study ID #: CEBC-CU-2017-04-18
• Status: Not yet recruiting
• Phase: N/A
• First received: May 4, 2017
• Last updated: May 6, 2017
• Start date: June 2017
• Est. completion date: February 2018

Study information

• Verified date: May 2017
• Source: Cairo University
• Contact: laura yehia zanati, master
• Phone: 01204470007
• Email: laura_lola92[@]yahoo.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.

Description:

.28 volunteer participants will be assigned in this study. Participants will be randomly divided into two groups(n=14) according to type of toothpaste D where groups D1 patient will use arginine containing toothpaste while groups D2 the patient will used the fluoride toothpaste with a number of 14 patients in each group. The pH will be evaluated according to time in relation to the brushing with toothpaste (T) where (T0) represent salivary pH before brushing with toothpaste , (T1) represent salivary pH 10 minutes after brushing with toothpaste at fixed time of the day.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 28
• Est. completion date: February 2018
• Est. primary completion date: December 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Participants should be over 18 years of age.

• Systematically healthy.

• Not taking any medication interfering with saliva secretion.

• Participants who signed informed consent.

Exclusion Criteria:

• Participants with a compromised medical history.

• Participants under systemic disease treatment, with antibiotic, steroid or any medication known to cause dry mouth.

• Severe or active periodontal disease.

• History of allergies or other adverse reactions to arginine, or oral care product or their ingredient.

Related Conditions & MeSH terms

• Dental Caries

Intervention

Drug:
• arginine toothpaste
acid neutralizer toothpaste
• fluoride toothpaste
bactericidal toothpaste

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	salivary pH	Salivary pH will be determined by use of a digital pH meter .All salivary pH values will be taken immediately following salivary collection at chairside. The salivary pH values measured before usage of toothpaste termed "resting pH," while the salivary pH values measured after usage of toothpaste termed "terminal pH.	10 minutes after intervention and control