Dental Caries Clinical Trial
Official title:
Interaction Chlorhexidine-fluoride - a 4-day and 6-week Randomised Clinical Mouthrinse Study
Verified date | October 2016 |
Source | University of Oslo |
Contact | n/a |
Is FDA regulated | No |
Health authority | Sweden: Central Ethical Review Board |
Study type | Interventional |
The aim of the present study was to study if there are interactions and reduced clinical effect between chlorhexidine and fluoride when they are combined in the same mouthrinse.
Status | Completed |
Enrollment | 32 |
Est. completion date | February 2012 |
Est. primary completion date | December 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Male and female subjects, age 18-35 years - Good general health - No signs of periodontitis and caries - A minimum of 24 teeth with no extensive restorations - No current or planned dental treatment during the trial periods. Exclusion Criteria: - Antibiotic treatment within 1 month prior to the start of the trial - Current medication with anti-inflammatory drugs - Use of antiseptic mouthrinses - Smokers and snuff user - Use of chewing gums |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Oslo | Göteborg University |
Axelsson P, Lindhe J. The effect of a preventive programme on dental plaque, gingivitis and caries in schoolchildren. Results after one and two years. J Clin Periodontol. 1974;1(2):126-38. — View Citation
Barkvoll P, Rölla G, Bellagamba S. Interaction between chlorhexidine digluconate and sodium monofluorophosphate in vitro. Scand J Dent Res. 1988 Feb;96(1):30-3. — View Citation
Dahlén G. Effect of antimicrobial mouthrinses on salivary microflora in healthy subjects. Scand J Dent Res. 1984 Feb;92(1):38-42. — View Citation
Dolles OK, Bonesvoll P, Gamst ON, Gjermo P. Determination of fluoride and chlorhexidine from chlorhexidine/fluoride-containing dentifrices. Scand J Dent Res. 1979 Apr;87(2):115-22. — View Citation
Emilson CG. Susceptibility of various microorganisms to chlorhexidine. Scand J Dent Res. 1977 May;85(4):255-65. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Plaque index | Baseline | No | |
Primary | Plaque index | Day 4 | No | |
Primary | Plaque index | Day 42 | No | |
Primary | Gingivitis index | Baseline | No | |
Primary | Gingivitis index | Day 42 | No | |
Secondary | Mutans streptococci counts in dental plaque and saliva | Day 0 | No | |
Secondary | Mutans streptococci counts in dental plaque and saliva | Day 4 | No | |
Secondary | Streptococcus sanguis counts in dental plaque and saliva | Day 42 | No | |
Secondary | Lactobacilli counts in dental plaque and saliva | Day 0 | No | |
Secondary | Lactobacilli counts in dental plaque and saliva | Day 4 | No | |
Secondary | Lactobacilli counts in dental plaque and saliva | Day 42 | No | |
Secondary | Streptococcus sanguinis counts in dental plaque and saliva | Day 0 | No | |
Secondary | Streptococcus sanguinis counts in dental plaque and saliva | Day 4 | No | |
Secondary | Streptococcus sanguinis counts in dental plaque and saliva | Day 42 | No | |
Secondary | Total bacterial counts in dental plaque and saliva | Day 0 | No | |
Secondary | Total bacterial counts in dental plaque and saliva | Day 4 | No | |
Secondary | Total bacterial counts in dental plaque and saliva | Day 42 | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04127929 -
Investigation of Glass Carbomer Performance
|
N/A | |
Completed |
NCT04769882 -
Er:YAG Laser Effects on Microbial Population in Conservative Dentistry
|
N/A | |
Completed |
NCT04971317 -
The Influence of Simple, Low-Cost Chemistry Intervention Videos: A Randomized Trial of Children's Preferences for Sugar-Sweetened Beverages
|
N/A | |
Active, not recruiting |
NCT04475679 -
Clinical Evaluation of Adhese Universal DC in the Indirect Restorative Therapy
|
N/A | |
Completed |
NCT05438381 -
Comparison of Clinical and Radiographic Outcomes of SMART Technique vs ART in Primary Molars
|
N/A | |
Not yet recruiting |
NCT03037814 -
Clinical Performance of Restorative Materials in Primary Teeth
|
N/A | |
Active, not recruiting |
NCT05202665 -
Resin Infiltration and Fluoride Varnish Lesion Arresting Efficacy on Non-cavitated Proximal Lesion
|
N/A | |
Terminated |
NCT01147835 -
Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers
|
N/A | |
Not yet recruiting |
NCT04033263 -
Maintaining Oral Health With Bio-products
|
N/A | |
Enrolling by invitation |
NCT04438252 -
Evaluation of Reliability of CarieScan PRO Compared With Digital Radiograph and ICDAS-II in Detection of Carious Lesions
|
N/A | |
Not yet recruiting |
NCT03609034 -
Knowledge, Attitude and Practice of a Group of Egyptian Dental Interns Toward Caries Risk Assessment
|
||
Completed |
NCT02912000 -
TEACH: Technology Evaluation to Address Child Health
|
N/A | |
Completed |
NCT02473107 -
Impact of Detecting Initial and Active Caries Lesions in Primary Teeth
|
N/A | |
Active, not recruiting |
NCT02537184 -
Impact of Two Recall Intervals on Dental Caries Incidence and Other Outcomes of Preschool Children
|
N/A | |
Completed |
NCT01950546 -
Nanosilver Fluoride to Prevent Dental Biofilms Growth
|
Phase 1 | |
Recruiting |
NCT02734420 -
Effect of Photodynamic Therapy With Low-level Laser on Infected Dentin in Primary Teeth: A Controlled Clinical Trial
|
Phase 1 | |
Completed |
NCT02020681 -
Effect of Curodont Repair or Placebo on the Remineralisation in Patients With Class 5 Carious Lesions
|
N/A | |
Completed |
NCT02426619 -
Arresting Active Dental Caries in Preschool Children by Topical Fluorides
|
Phase 2/Phase 3 | |
Completed |
NCT02234609 -
Effectiveness of Modified Class IV Atraumatic Restorative Treatment
|
N/A | |
Completed |
NCT01268605 -
Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial
|
Phase 3 |