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Dental Caries in Children clinical trials

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NCT ID: NCT06412731 Active, not recruiting - Clinical trials for Dental Caries in Children

Comparing the Effectiveness of Papain Based Chemico-mechanical Caries Removal Gel and 38% Silver Diamine Fluoride for Treating Active Caries Lesion of Primary Molars

Start date: January 2, 2024
Phase: N/A
Study type: Interventional

This study aims to investigate the efficacy of silver diamine fluoride (SDF) and Papain-based chemico-mechanical caries removal gel and using ceramic bur as a control in treating dentine caries in primary molars aged 7-8 years children. by investigating the following outcomes: 1. Arrestment of caries lesion and the emergence of a new one 2. Time required for the treatment 3. Adverse events 4. Children's anxiety

NCT ID: NCT06305845 Active, not recruiting - Clinical trials for Dental Caries in Children

Digital Crowns Versus Prefabricated Crowns on Primary Teeth

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

Badly decayed primary molars will be treated by performing the pulp therapy technique indicated, then the patients will be randomized into two groups to receive the restorative intervention. For the intervention group, teeth will be prepared to receive the digital crown after intraoral scanning while for the control group, teeth will be prepared to receive the prefabricated zirconia crowns. Teeth will be followed up clinically for 1 year, at 1, 6 and 12 months.

NCT ID: NCT06068244 Active, not recruiting - Clinical trials for Dental Caries in Children

3D-printed Crowns Versus Zirconia Crowns for Primary Molars

Start date: July 1, 2023
Phase: N/A
Study type: Interventional

The aim of the present study is to compare between 3D-printed crowns and prefabricated zirconia crowns for restoring pulpally-treated primary molars regarding the following aspects: 1. In vivo: Evaluate the clinical outcome of 3D printed crowns in comparison to prefabricated zirconia crowns in pulpally-treated primary molars as well as parent satisfaction. 2. In vitro: Comparative analysis of fracture resistance and marginal gap of 3D printed crowns and prefabricated zirconia crowns

NCT ID: NCT05902975 Active, not recruiting - Clinical trials for Dental Caries in Children

Evaluation of the Antimicrobial Fiber Reinforced Composite Resin Space Maintainer Modified With Silver Nano Particles

Start date: May 21, 2022
Phase: N/A
Study type: Interventional

Fiber reinforced composite resin space maintainer

NCT ID: NCT05670743 Active, not recruiting - Clinical trials for Dental Caries in Children

Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age

Start date: March 1, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to further characterize basic pharmacokinetic (PK) parameters in healthy children to contribute to evidence for the safety of silver diamine fluoride (SDF; Advantage Arrest). Children with at least one active cavity will be treated and then have blood draws at random time points afterwards.

NCT ID: NCT05220865 Active, not recruiting - Clinical trials for Dental Caries in Children

Hall Technique or Modified Hall Technique of Deep Carious Lesions in Primary Molars

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this randomized clinical trial is to compare the clinical/radiographic success of Hall technique and modified Hall technique in the treatment of primary molars with deep dentine carious lesions in children (3-12-year-old). The secondary aim is to examine the effect of marginal ridge breakdown level on treatment success.

NCT ID: NCT05121584 Active, not recruiting - Clinical trials for Dental Caries in Children

Evaluation of Two Different Types of Zirconia Crowns Used in Carious Primary Anterior Teeth

Start date: November 20, 2020
Phase: N/A
Study type: Interventional

Evaluation of two different types of zirconia crowns ( Kinder Krown , Nusmile crown) used in carious primary anterior teeth

NCT ID: NCT04947527 Active, not recruiting - Clinical trials for Dental Caries in Children

Efficacy and Safety Evaluation of Anti-Caries Varnish

Start date: June 4, 2022
Phase: Phase 2
Study type: Interventional

The purpose of the study is to determine the efficacy & safety of Advantage Anti-Caries Varnish for primary prevention. The objectives are: 1) To determine if Advantage Anti-Caries Varnish (test varnish) is superior to an active control varnish (5% Sodium Fluoride, no Povidone-Iodine) in the prevention of caries lesions in the primary dentition. Specifically, prevention of caries lesions in primary teeth that either are sound, have only d1 (white spots) lesions or unerupted at baseline; and 2) To document the safety of the test varnish.

NCT ID: NCT04933331 Active, not recruiting - Dental Caries Clinical Trials

Early Caries Lesion Management Observational Study

ELMO
Start date: December 7, 2020
Phase:
Study type: Observational

The purpose of this observational study is to assess the effectiveness of Curodont Repair Fluoride Plus (CRFP) compared to other tooth-specific treatments (silver diamine fluoride (SDF), sealants, or other FDA-approved treatments) in preventing progression to cavitation in patients with at least one early non-cavitated dental caries lesion. The study will also evaluate the effectiveness of CRFP in comparison to no tooth-specific treatment control groups, including whole mouth treatments such as: 2.26% fluoride varnish, 1.23% fluoride foam, and 5000 ppm fluoride prescription toothpaste; and no treatment, on caries arrest and in preventing progression to cavitation in patients with at least one early non-cavitated dental lesion.

NCT ID: NCT04766775 Active, not recruiting - Clinical trials for Dental Caries in Children

The Pharmacokinetics of Silver Diamine Fluoride (SDF) in Healthy Children

SDF
Start date: July 3, 2020
Phase: N/A
Study type: Interventional

This study focus on the pharmacokinetic characteristic of silver diamine fluoride (SDF) in healthy children. All of the children received treatment for the decayed teeth in the same way. A medication called silver diamine fluoride is used to treat the decayed teeth. It contains a high concentration of fluoride (range from 14100 ppm to 51013 ppm) and silver. This medication halts the decay process through the combined effects of anti-bacterial from silver and remineralization from fluoride. As this product contains the highest concentration of fluoride level found in the market and the metal element of silver, the investigators aim to study the body's reaction towards SDF. The investigators collect the hair and urine samples at different time points and then analyze them to determine the silver and/or fluoride levels. The outcomes include 1. the silver level in the hair and urine samples 2. the fluoride level in the urine samples. The investigators analyze the silver level in hair and urine samples using Inductively Coupled Plasma Mass Spectrometry (ICP-MS); fluoride level in urine samples using Ion-Selective Electrode.