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Clinical Trial Summary

This study is designed as a long-term extension to Study APL2-C3G-310, and is being conducted to establish the long-term safety and efficacy of pegcetacoplan in patients with C3 glomerulopathy (C3G) or immune-complex membranoproliferative glomerulonephritis (IC-MPGN).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05809531
Study type Interventional
Source Apellis Pharmaceuticals, Inc.
Contact
Status Active, not recruiting
Phase Phase 3
Start date May 29, 2023
Completion date July 2027

See also
  Status Clinical Trial Phase
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Recruiting NCT06065852 - National Registry of Rare Kidney Diseases
Not yet recruiting NCT05647811 - Study of NM8074 in Adult C3 Glomerulopathy Patients Phase 1/Phase 2
Active, not recruiting NCT05067127 - Phase III Study Assessing the Efficacy and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis Phase 3
Recruiting NCT06209736 - Safety and Efficacy Study of OMS906 in Patients With C3G and ICGN Phase 2
Terminated NCT03459443 - A Proof of Concept Study for a 12 Month Treatment in Patients With C3G or IC-MPGN Treated With ACH-0144471 Phase 2
Completed NCT03369236 - A Proof-of-Concept Study of Danicopan for 6 Months of Treatment in Participants With C3 Glomerulopathy (C3G) Phase 2
Active, not recruiting NCT04572854 - Study Assessing the Safety and Efficacy of Pegcetacoplan in Post-Transplant Recurrence of C3G or IC-MPGN Phase 2
Recruiting NCT02682407 - Safety Study of IgAN, LN, MN, & C3 Glomerulopathy Including Dense Deposit Disease Treated With OMS721 Phase 2
Recruiting NCT05083364 - Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease Phase 1
Completed NCT03723512 - Non-contrast Enhanced MRI in Patients With C3 Glomerulopathy (C3G) or Immune-complex Membranoproliferative Glomerulonephritis (IC-MPGN) Enrolled in the ACH471-205 Study N/A
Completed NCT03124368 - A Proof-of-Mechanism Study to Determine the Effect of Danicopan on C3 Levels in Participants With C3G or IC-MPGN Phase 2
Available NCT04729062 - C3G/Primary IC-MPGN EAP