Delivery of Health Care Clinical Trial
Official title:
Effect of Dietary Supplement Limicol on LDL-cholesterol Levels in Moderate Hypercholesterolaemia
The purpose of this study is to validate the effectiveness of food supplement Limicol on reducing LDL-cholesterol in moderate hypercholesterolemic volunteers.
Cardiovascular disease (CVD), foremost among which ischemic heart disease and stroke, are
the leading cause of mortality and morbidity in France. These diseases are multifactorial
origin and even if it is not possible to act on risk markers such as age, sex, or heredity,
risk factors like high cholesterol, smoking , hypertension, obesity, diabetes and physical
inactivity, are the main target of prevention strategies.The dydlipidémies have a role in
the formation of CVD in participating in the genesis of atherosclerosis. The cholesterol and
LDL-cholesterol in particular is subject to oxidation process in plasma. The molecules of
oxidized LDL-cholesterol, small and dense, easily penetrate the arterial endothelial wall
and are greeted by macrophages. Following a succession of different processes including
inflammation, atherosclerotic plaque is formed. The result is either an arteriopathy when
the arterial lumen narrowing, or atherothrombosis in the event of plaque rupture. Given this
pathophysiology, reduce blood lipids, including LDL-cholesterol and reducing oxidation and
inflammation are interesting strategies in the context of cardiovascular prevention. Several
scientific study showed that nutritional supplementation with some plant extracts such as
artichokes, garlic, red yeast rice, or the sugar cane policosanol helps to reduce several
cardiovascular risk factors including regulate concentrations of circulating lipids.
The objective of this study is to validate the effectiveness of Limicol, formulated with
proven scientific data on the reduction of LDL-cholesterol in volunteers with moderate
hypercholesterolaemia (LDL-cholesterol).
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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