Delirium Clinical Trial
Official title:
Perioperative Salivary Alpha-amylase as a Predictor of Delirium After Lower Extremity Vascular Bypass Surgery
The aim of this study is to evaluate the role of salivary Alpha-amylase as a predictor biomarker of POD in elderly patients undergoing limb bypass surgery.
Status | Not yet recruiting |
Enrollment | 60 |
Est. completion date | July 1, 2024 |
Est. primary completion date | July 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 65 Years and older |
Eligibility | Inclusion Criteria: - Age = 65 years. - Both sexes. - American Society of Anesthesiologists (ASA) physical status III. - Undergoing lower extremity vascular surgery under general anesthesia. Exclusion Criteria: - Patients who used any medication that could affect salivary glands (such as antihypertensive, antidepressants or antipsychotic drugs). - Inability to communicate. - History of psychiatric diseases or previous stroke - Previous history of pod. - Those with smoking and drinking habits. - Pregnant female. |
Country | Name | City | State |
---|---|---|---|
Egypt | Tanta University | Tanta | El-Gharbia |
Lead Sponsor | Collaborator |
---|---|
Tanta University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The accuracy of salivary alpha-amylase as a predictor of postoperative delirium | The accuracy of salivary alpha-amylase will be measured by saliva samples which will be obtained using a saliva collection system and SAA level will be measured preoperatively, immediately postoperative, at the end of the 1st, 2nd, and 3rd postoperative days. | 3rd day postoperatively | |
Secondary | Incidence of postoperative delirium | Incidence of postoperative delirium will be measured. | 24 hours postoperatively | |
Secondary | Correlation of salivary alpha-amylase with C-reactive protein | Correlation of salivary alpha-amylase with C-reactive protein will be assessed. | 24 hours postoperatively | |
Secondary | Correlation of salivary alpha-amylase with average pain score | Correlation of salivary alpha-amylase with average pain score will be assessed. Pain score will be assessed using numeric rating scale (NRS) score. NRS (0 represents "no pain" while 10 represents "the worst pain imaginable. | 24 hours postoperatively | |
Secondary | Correlation of salivary alpha-amylase with morphine consumption | Correlation of salivary alpha-amylase with morphine consumption will be assessed. | 24 hours postoperatively |
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