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NCT06194474 Clinical Trial

Study on Biomarkers of Postoperative Delirium in Elderly Cardiac Surgery Patients

Delirium Clinical Trial

Official title:
Study on Biomarkers of Postoperative Delirium in Elderly Cardiac Surgery Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06194474
Other study ID # JNFPH-2023-01
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date September 5, 2022
Est. completion date February 2024

Study information
Verified date January 2024
Source Jining First People's Hospital
Contact Fuhui Yan
Phone 155 8733 5175
Email richardcarryon@163.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To evaluate the relationship between abnormal protein or metabolite expression levels in peripheral blood and postoperative delirium in elderly patients undergoing cardiac surgery.

Recruitment information / eligibility
Status Recruiting
Enrollment 24
Est. completion date February 2024
Est. primary completion date February 2024
Accepts healthy volunteers No
Gender All
Age group 55 Years to 80 Years
Eligibility Inclusion Criteria: 1. patients between 55 and 80 years old, 2. American Society of Anesthesiologists (ASA) physical status of II-III and New York Heart Association grade of II-III. 3. The planned cardiac surgery. 4. Hospitalization duration not less than 5 days. 5. The anesthesia time will be no less than 2 hours.All patients had a normal ability to hear, read and cooperate with neuropsychological tests. Exclusion Criteria: 1. The pre-operative Montreal Cognitive Assessment (MoCA) score was less than 25, 2. Patients with dementia, history of neurological or psychiatric disease, hospital with anxiety depression scale (HADS) over eight points, 3. Currently use sedatives or antidepressants, Patients with substance dependence on drugs or alcohol. 4. Patients with liver and kidney dysfunction, patients with a history of cardiac surgery. 5. Admitted to the ICU for more than two days within the month preceding the current surgery, 6. Unable to cooperate with researcher's investigations.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
China Fuhui Yan Jining Shandong

Sponsors (1)
Lead Sponsor Collaborator
Jining First People's Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Proteomics Proteomic data will be obtained by LC-MS/MS Analysis-DIA(Data Independent Acquisition) platform 1 month
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