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Clinical Trial Summary

Delirium is an extremely common complication in mechanically ventilated ICU patients, which can decrease the patients' cognitive function, prolong hospitalization, and even increase mortality. But there is currently no validated treatment for delirium. Therefore, this study aims to build a multi-modal virtual reality (VR) intervention environment to conduct comprehensive interventions in psychological, physiological, and cognitive aspects for ICU mechanically intubated patients, which will be used to improve the hospitalization experience, reduce the prevalence of delirium, and decrease the duration of ICU stay of patients on mechanical ventilation.


Clinical Trial Description

Firstly, the investigators will explore the synergistic mechanism among the sense of presence in virtual environments (VEs), the factor of emotion induction, and the cognitive activation of the neural system for building a beneficial VE for the patients' mental health. On this basis, the investigators will provide the social connection for mechanical ventilation patients by applying cross-platform collaboration VR technology, thereby reducing the negative impact of social isolation, improving the psychological loneliness caused by the separation of family members and patients in the epidemic, and improving the mental health of patients. In terms of physiology, this study will use VR pain distraction technology to improve analgesia in ICU mechanically ventilated patients based on attention-shifting mechanisms. Finally, the investigators will use the paradigm of psychological relief, physiological analgesia, and neurocognitive activation to construct a comprehensive VR cognitive aided diagnosis and cognitive intervention system, and try to assist in the diagnosis and intervention of delirium. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05525702
Study type Interventional
Source Peking Union Medical College Hospital
Contact Yingying Yang, MD
Phone +8618800173833
Email yangyingying2703@outlook.com
Status Recruiting
Phase N/A
Start date April 18, 2022
Completion date April 17, 2024

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