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NCT05060614 Clinical Trial

Analyses of Cerebrospinalfluid in Patients With Delirium

Delirium Clinical Trial

Official title:
MOLECULAR BIOMARKERS IN DELIRIUM AND DEMENTIA

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05060614
Other study ID # 2016/1368
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date September 1, 2016
Est. completion date December 30, 2027

Study information
Verified date March 2024
Source Oslo University Hospital
Contact Leiv O Watne, PhD
Phone 40203712
Email l.o.watne@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The current project aims to measure biomarkers in the cerebrospinalfluid (CSF) and serum samples from patients with delirium. We hope to uncover new insights into the pathophysiology of delirium and explore its link to dementia.

Description:

Delirium is a common and serious complication to acute illness, and is characterized by acute disturbances in attention, awareness, and cognition. Dementia is a major risk factor of delirium, and delirium increases the risk of dementia progression and development. As the conditions share both clinical and epidemiological features, some researchers suggest that also pathophysiological links are shared. Understanding delirium pathophysiology, which is poorly understood, may thus help elucidate early molecular mechanisms in dementia. This study aims to to increase our understanding of the pathophysiology of delirium and molecular links between delirium and dementia, by exploring cerebrospinal fluid (CSF) biomarkers.

Recruitment information / eligibility
Status Recruiting
Enrollment 700
Est. completion date December 30, 2027
Est. primary completion date December 30, 2027
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Patients with acute hip fracture Exclusion Criteria: - Moribund patients. - Lack of consent

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Hip fracture surgery
Hip fracture surgery

Locations
Country Name City State
Norway Leiv Otto Watne Oslo Other

Sponsors (1)
Lead Sponsor Collaborator
Oslo University Hospital

Country where clinical trial is conducted

Norway, 

Outcome
Type Measure Description Time frame Safety issue
Primary Delirium Pre- and postoperative delirium Daily during hospital stay (pre-/and postoperatively) until 5 days after surgery (or discharge)
Secondary Dementia Incident dementia Cognitive changes the first 48 months after inclusion
See also
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Terminated NCT03337282 - Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
Not yet recruiting NCT04846023 - Pediatric Delirium Screening in the PICU Via EEG N/A
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Withdrawn NCT02673450 - PER3 Clock Gene Polymorphism, Clock Gene Expression and Delirium in the Intensive Care Unit.
Recruiting NCT03256500 - Transcranial Direct Current Stimulation for the Treatment of Delirium N/A
Completed NCT02890927 - Geriatric-CO-mAnagement for Cardiology Patients in the Hospital N/A
Not yet recruiting NCT02892968 - ED Ultrasonographic Regional Anesthesia to Prevent Incident Delirium in Hip Fracture Patients N/A
Recruiting NCT03165539 - Cerebral Oxygen Desaturation and Post-Operative Delirium in Thoracic Surgical Patients
Completed NCT02554253 - The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction Phase 2
Completed NCT02518646 - DElirium prediCtIon in the intenSIve Care Unit: Head to Head comparisON of Two Delirium Prediction Models N/A
Recruiting NCT02305589 - The Clinical Changes Before and After Sugammadex in the Patients Undergoing Hip Surgery on the Aspect of Delirium N/A
Completed NCT02628925 - Nu-DESC DK: The Danish Version of the Nursing Delirium Screening Scale N/A