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NCT04127500 Clinical Trial

The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery

Delirium Clinical Trial

Official title:
The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04127500
Other study ID # KY20190823-04
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date August 1, 2019
Est. completion date August 31, 2020

Study information
Verified date October 2019
Source Nanjing First Hospital, Nanjing Medical University
Contact Qiankun Shi, Doctor
Phone +8613851420762
Email hlblade@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators aim to evaluate the roles of α7nAchR in the mechanisms of dexmedetomidine in improving delirium after cardiac surgery. The results of this study would lay the foundation for revealing the mechanisms of dexmedetomidine improving delirium after cardiac surgery and provide a new idea to the early treatment of delirium.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date August 31, 2020
Est. primary completion date July 31, 2020
Accepts healthy volunteers No
Gender All
Age group 60 Years to 100 Years
Eligibility Inclusion Criteria:

- ICU patients underwent cardiac surgery

- age = 60 years

Exclusion Criteria:

- Preoperative cognitive decline, mental illness,

- preoperative long-term use of hormone patients,

- preoperative alcohol dependence,

- patients with alcohol withdrawal symptoms

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• dexmedetomidine
dexmedetomidine

Locations
Country Name City State
China Nanjing First Hospital Nanjing Jiangsu

Sponsors (1)
Lead Sponsor Collaborator
Nanjing First Hospital, Nanjing Medical University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary delirium incidence 1 month
Primary a7nAChR level 7 days
Secondary mechanical ventilation time 7 days
Secondary ICU stay time 1 month
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