Clinical Trials Logo
  1. Home
  2. Delirium
  3. NCT02394418
  4. Details
NCT02394418 Clinical Trial

Effect of Sevoflurane, Propofol and Dexmedetomidine on Delirium & Neuroinflammation in Mechanically Ventilated Patients

Delirium Clinical Trial

Official title:
Comparison of Sedative Effects of Sevoflurane, Propofol and Dexmedetomidine on the Clinical Course of Delirium and Neuroinflammation in Mechanically Ventilated Patients

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT02394418
Other study ID # S-D-P-MV-220115
Secondary ID
Status Withdrawn
Phase Phase 4
First received
Last updated
Start date September 1, 2017
Est. completion date August 2018

Study information
Verified date August 2019
Source Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Assessment of sedative effects of sevoflurane, dexmedetomidine and propofol on the clinical course of delirium, SIRS and neuroinflammation in mechanically ventilated patients using CAM-ICU scale, GSK-3beta and protein S100b in serum.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date August 2018
Est. primary completion date May 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- presence of delirium

Exclusion Criteria:

- presence of Alzheimer's disease

- any mental disorder

- presence of cancer

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Sevoflurane
Treatment of delirium by inhaled sevoflurane
• Propofol
Treatment of delirium by propofol i.v. infusion
• Dexmedetomidine
Treatment of delirium by dexmedetomidine i.v. infusion

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy

Outcome
Type Measure Description Time frame Safety issue
Primary Duration of Delirium Delirium assessment by CAM-ICU scale up to 5 days
Secondary Change of protein S100b in serum from delirium onset up to 5 days
Secondary Change of GSK-3beta in serum from delirium onset up to 5 days
See also
  Status Clinical Trial Phase
Completed NCT04551508 - Delirium Screening 3 Methods Study
Recruiting NCT05891873 - Delirium in the (Neuro)Intensive/Critical Care in the Adult and Paediatric Czech Populations
Recruiting NCT06027788 - CTSN Embolic Protection Trial N/A
Recruiting NCT04792983 - Cognition and the Immunology of Postoperative Outcomes
Recruiting NCT06194474 - Study on Biomarkers of Postoperative Delirium in Elderly Cardiac Surgery Patients
Completed NCT03095417 - Improving the Recovery and Outcome Every Day After the ICU N/A
Completed NCT05395559 - Prevalence and Recognition of Cognitive Impairment in Hospitalized Patients: a Flash Mob Study
Terminated NCT03337282 - Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
Not yet recruiting NCT04846023 - Pediatric Delirium Screening in the PICU Via EEG N/A
Not yet recruiting NCT04538469 - Absent Visitors: The Wider Implications of COVID-19 on Non-COVID Cardiothoracic ICU Patients, Relatives and Staff
Not yet recruiting NCT03807388 - ReMindCare App for Patients From First Episode of Psychosis Unit. N/A
Withdrawn NCT02673450 - PER3 Clock Gene Polymorphism, Clock Gene Expression and Delirium in the Intensive Care Unit.
Recruiting NCT03256500 - Transcranial Direct Current Stimulation for the Treatment of Delirium N/A
Not yet recruiting NCT02892968 - ED Ultrasonographic Regional Anesthesia to Prevent Incident Delirium in Hip Fracture Patients N/A
Completed NCT02890927 - Geriatric-CO-mAnagement for Cardiology Patients in the Hospital N/A
Recruiting NCT03165539 - Cerebral Oxygen Desaturation and Post-Operative Delirium in Thoracic Surgical Patients
Completed NCT02554253 - The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction Phase 2
Completed NCT02518646 - DElirium prediCtIon in the intenSIve Care Unit: Head to Head comparisON of Two Delirium Prediction Models N/A
Recruiting NCT02305589 - The Clinical Changes Before and After Sugammadex in the Patients Undergoing Hip Surgery on the Aspect of Delirium N/A
Completed NCT02628925 - Nu-DESC DK: The Danish Version of the Nursing Delirium Screening Scale N/A