Delirium Clinical Trial
Official title:
Risk of QT-prolongation and Torsade de Pointes in Patients Treated With Acute Medication in a University Hospital
A prospective, observational study in a university hospital (UZ Leuven). Patients are
included when they are treated with a potentional QT-prolonging drug: haloperidol for
delirium, antibiotics (moxifloxacin, levofloxacin, azithromycin, clarithromycin,
erythromycin, co-trimoxazole), antimycotics (ketoconazole, itraconazole, fluconazole,
voriconazole), methadone, tacrolimus and oral oncolytics.
An ECG is taken before the administration of the drug and 3-5 days after starting the drug
to investigate the change in duration of the QTc-interval. Risk factors for developing
QT-prolongation will be documented. Together with ECG2, an additional blood sample will be
collected to measure the blood concentration of the drug.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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