Efficacy of the Administration of Melatonin 5mg in the Prevention of

Status Recruiting

Clinical Trial Summary

This study evaluates the efficacy of melatonin 5mg in the prevention of Delirium in the older adults in emergency department. Half of the participants will receive melatonin 5mg and the other half will use a starch-based placebo.

Clinical Trial Description

Melatonia is useful for the treatment of sleep disorders due to the interruption of the circadian rhythm, secondary to alterations caused by the environment. The doses of 5 to 10mg oral or sublingual can improve the quality of the sleep-wake cycle and alertness in short-term use.

Mechanism of action of melatonin are:

1. Binding to membrane receptors: MT1 and MT2 coupled to G protein

2. - Union to nuclear receptors.

3. - Interaction with cytosolic proteins.

4. - Antioxidant of direct and indirect action.

5. - Interaction with mitochondria.

Melatonin circulates 80% bound to albumin and the rest in free form in plasma, 85-90% is metabolized by 6-hydroxymelatonin in the liver, which is then conjugated with sulfuric acid (70-80%) or glucuronic ( 5-3%), and is excreted in urine and feces.

Melatonin and its metabolites act as catalytic antioxidants to safeguard mitochondrial electron transfer reactions, therefore, increases the efficiency of energy metabolism. Melatonin synthesis decreases significantly as age progresses and changes in the circadian cycle have been associated with accelerated aging. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04187807
Study type	Interventional
Source	Universidad Autonoma de San Luis Potosí
Contact	Fatima A Sánchez, Doctor of medicinen
Phone	4441777616
Email	alon118@hotmail.com
Status	Recruiting
Phase	N/A
Start date	October 10, 2019
Completion date	May 2020

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Efficacy of the Administration of Melatonin 5mg in the Prevention of Delirium in Older Adults Hospitalized in the Emergency Department

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms