Delayed Type Hypersensitivity Clinical Trial
Official title:
Characterization of the Molecular Mechanisms Involved in Delayed-Type Hypersensitivity Reactions to House Dust Mite, Diphencyprone, Nickel, and Tuberculin Purified Protein Derivative in Healthy Volunteers
This study will be conducted in 2 cohorts.
In Cohort A, approximately 40 subjects will participate in a single-center, open-label,
non-randomized, parallel-group trial to investigate the molecular mechanisms involved in
delayed-type hypersensitivity (DTH) to various antigens and assess the most appropriate skin
challenge antigen to study the effect of systemic treatments on T cells.
Following evaluation of the results in Cohort A, approximately 20 healthy volunteers will be
enrolled in Cohort B. This cohort will be a single-center, double-blind, randomized, two-arm,
placebo-controlled study to evaluate the effect of corticosteroid treatment on the molecular
and cellular phenotype of delayed hypersensitivity response to one if the antigens previously
studied in Cohort A.
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