Monosodium Glutamate on Gastric Emptying

Delayed Gastric Emptying Clinical Trial

Official title:

Effect of a Single Dose of Monosodium Glutamate on Delayed Gastric Emptying in Children

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT02745028
• Other study ID #: 2404
• Status: Withdrawn
• Phase: N/A
• Start date: April 2016
• Est. completion date: October 2017

Study information

• Verified date: February 2023
• Source: Hospital Italiano de Buenos Aires
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Children with a radionuclide gastric emptying test with abnormal results will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. The purpose of the study is to determine if a single dose of monosodium glutamate can shorten the gastric emptying time.

Description:

There is evidence that monosodium glutamate has effects on synapsis at the gastric and duodenum level that results in stimulation of contractility resulting on increase rate of gastric emptying. The purpose of the study is to demonstrate that the administration of a single dose of monosodium glutamate can shorten the gastric emptying time.

Patients with a prior study indicating a delay of gastric empting time, will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. Each patient will serve as her/his own control. Results will be analysed by pair-T test.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: October 2017
• Est. primary completion date: October 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 12 Months to 17 Years

Eligibility

Inclusion Criteria:

• children with delayed gastric emptying not receiving prokinetic medication in the last 72 hours

Exclusion Criteria:

• Prior gastrointestinal surgery, patients with known history of reaction to monosodium glutamate. History of neoplasia, autoimmune or inflammatory bowel disease.

Related Conditions & MeSH terms

• Delayed Gastric Emptying
• Gastroparesis

Intervention

Dietary Supplement:
• Monosodium glutamate
A single dose of weight adjusted monosodium glutamate will be added at the time of a repeat radionuclide gastric emptying study

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Veronica Beatriz Busoni	International Glutamate Technical Committee

References & Publications (4)

Boutry C, Matsumoto H, Airinei G, Benamouzig R, Tome D, Blachier F, Bos C. Monosodium glutamate raises antral distension and plasma amino acid after a standard meal in humans. Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G137-45. doi: 10.1152/ — View Citation

Hosaka H, Kusano M, Zai H, Kawada A, Kuribayashi S, Shimoyama Y, Nagoshi A, Maeda M, Kawamura O, Mori M. Monosodium glutamate stimulates secretion of glucagon-like peptide-1 and reduces postprandial glucose after a lipid-containing meal. Aliment Pharmacol — View Citation

Teramoto H, Shimizu T, Yogo H, Nishimiya Y, Hori S, Kosugi T, Nakayama S. Gastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects. Physiol Rep. 2014 Jan 6;2(1):e00187. doi: 10.1002/phy2.187. eColle — View Citation

Zai H, Kusano M, Hosaka H, Shimoyama Y, Nagoshi A, Maeda M, Kawamura O, Mori M. Monosodium L-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying. Am J Clin Nutr. 2009 Jan;89(1):431-5. doi: 10.3945/ajcn.2008.26180. Epub 200 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reduced gastric emptying time	Percentage of reduction of gastric emptying time when glutamate is administered compared to baseline	During the test (4 hours from intake)

External Links

•   Questions and Answers on Monosodium glutamate